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Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder
The loss of dopamine in the striatum underlies motor symptoms of Parkinson’s disease (PD). Rapid eye movement sleep behaviour disorder (RBD) is considered prodromal PD and has shown similar neural changes in the striatum. Alterations in brain iron suggest neurodegeneration; however, the literature o...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568416/ https://www.ncbi.nlm.nih.gov/pubmed/37797434 http://dx.doi.org/10.1016/j.nicl.2023.103519 |
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author | Alushaj, Erind Hemachandra, Dimuthu Kuurstra, Alan Menon, Ravi S. Ganjavi, Hooman Sharma, Manas Kashgari, Alia Barr, Jennifer Reisman, William Khan, Ali R. MacDonald, Penny A. |
author_facet | Alushaj, Erind Hemachandra, Dimuthu Kuurstra, Alan Menon, Ravi S. Ganjavi, Hooman Sharma, Manas Kashgari, Alia Barr, Jennifer Reisman, William Khan, Ali R. MacDonald, Penny A. |
author_sort | Alushaj, Erind |
collection | PubMed |
description | The loss of dopamine in the striatum underlies motor symptoms of Parkinson’s disease (PD). Rapid eye movement sleep behaviour disorder (RBD) is considered prodromal PD and has shown similar neural changes in the striatum. Alterations in brain iron suggest neurodegeneration; however, the literature on striatal iron has been inconsistent in PD and scant in RBD. Toward clarifying pathophysiological changes in PD and RBD, and uncovering possible biomarkers, we imaged 26 early-stage PD patients, 16 RBD patients, and 39 age-matched healthy controls with 3 T MRI. We compared mean susceptibility using quantitative susceptibility mapping (QSM) in the standard striatum (caudate, putamen, and nucleus accumbens) and tractography-parcellated striatum. Diffusion MRI permitted parcellation of the striatum into seven subregions based on the cortical areas of maximal connectivity from the Tziortzi atlas. No significant differences in mean susceptibility were found in the standard striatum anatomy. For the parcellated striatum, the caudal motor subregion, the most affected region in PD, showed lower iron levels compared to healthy controls. Receiver operating characteristic curves using mean susceptibility in the caudal motor striatum showed a good diagnostic accuracy of 0.80 when classifying early-stage PD from healthy controls. This study highlights that tractography-based parcellation of the striatum could enhance sensitivity to changes in iron levels, which have not been consistent in the PD literature. The decreased caudal motor striatum iron was sufficiently sensitive to PD, but not RBD. QSM in the striatum could contribute to development of a multivariate or multimodal biomarker of early-stage PD, but further work in larger datasets is needed to confirm its utility in prodromal groups. |
format | Online Article Text |
id | pubmed-10568416 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-105684162023-10-13 Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder Alushaj, Erind Hemachandra, Dimuthu Kuurstra, Alan Menon, Ravi S. Ganjavi, Hooman Sharma, Manas Kashgari, Alia Barr, Jennifer Reisman, William Khan, Ali R. MacDonald, Penny A. Neuroimage Clin Regular Article The loss of dopamine in the striatum underlies motor symptoms of Parkinson’s disease (PD). Rapid eye movement sleep behaviour disorder (RBD) is considered prodromal PD and has shown similar neural changes in the striatum. Alterations in brain iron suggest neurodegeneration; however, the literature on striatal iron has been inconsistent in PD and scant in RBD. Toward clarifying pathophysiological changes in PD and RBD, and uncovering possible biomarkers, we imaged 26 early-stage PD patients, 16 RBD patients, and 39 age-matched healthy controls with 3 T MRI. We compared mean susceptibility using quantitative susceptibility mapping (QSM) in the standard striatum (caudate, putamen, and nucleus accumbens) and tractography-parcellated striatum. Diffusion MRI permitted parcellation of the striatum into seven subregions based on the cortical areas of maximal connectivity from the Tziortzi atlas. No significant differences in mean susceptibility were found in the standard striatum anatomy. For the parcellated striatum, the caudal motor subregion, the most affected region in PD, showed lower iron levels compared to healthy controls. Receiver operating characteristic curves using mean susceptibility in the caudal motor striatum showed a good diagnostic accuracy of 0.80 when classifying early-stage PD from healthy controls. This study highlights that tractography-based parcellation of the striatum could enhance sensitivity to changes in iron levels, which have not been consistent in the PD literature. The decreased caudal motor striatum iron was sufficiently sensitive to PD, but not RBD. QSM in the striatum could contribute to development of a multivariate or multimodal biomarker of early-stage PD, but further work in larger datasets is needed to confirm its utility in prodromal groups. Elsevier 2023-09-28 /pmc/articles/PMC10568416/ /pubmed/37797434 http://dx.doi.org/10.1016/j.nicl.2023.103519 Text en © 2023 The Authors. Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Regular Article Alushaj, Erind Hemachandra, Dimuthu Kuurstra, Alan Menon, Ravi S. Ganjavi, Hooman Sharma, Manas Kashgari, Alia Barr, Jennifer Reisman, William Khan, Ali R. MacDonald, Penny A. Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder |
title | Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder |
title_full | Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder |
title_fullStr | Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder |
title_full_unstemmed | Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder |
title_short | Subregional analysis of striatum iron in Parkinson’s disease and rapid eye movement sleep behaviour disorder |
title_sort | subregional analysis of striatum iron in parkinson’s disease and rapid eye movement sleep behaviour disorder |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568416/ https://www.ncbi.nlm.nih.gov/pubmed/37797434 http://dx.doi.org/10.1016/j.nicl.2023.103519 |
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