Effect of PENN-DIABEX, a novel polyherbal formulation, in high fat diet streptozotocin-induced diabetic rats

Diabetes, a chronic metabolic disorder affecting millions worldwide, presents a significant health challenge characterized by impaired glucose regulation and potential complications. This study examines the antidiabetic effects of a polyherbal formulation (PENN-DIABEX) prepared from five different medicinal plant extracts. The objective is to ascertain its efficacy in managing streptozotocin (STZ) induced diabetes in rats. To accomplish this, six distinct groups of rats were involved five with induced diabetes and one serving as a normal control. Among the diabetic groups, one received no treatment, functioning as the diabetic control group. The remaining three groups were administered PHF in three different doses while the 6th group was given metformin. On the last day of the experiment, all rats were sacrificed, and blood samples were taken in collecting tubes to analyze blood biochemical parameters. Additionally, tissue samples from the liver, kidney, and pancreas were preserved in formalin solution for subsequent histopathological activity. The results of the study revealed that treatment with PHF in diabetic rats led to a significant (P < 0.01) improvement in fasting blood glucose levels (FBG), glycated hemoglobin (HbA1c), and various biochemical markers including LFTs, RFTs, and lipid profiling. Furthermore, the histology of the liver, kidney, and pancreas indicated that the formulation did not induce any metabolic toxicity. Comparative analysis of the antidiabetic effects of PHF with those of metformin, revealed that the PHF showed better results than the standard drug. This suggests its potential utilization as a safer and alternative approach in the treatment of diabetes.