Inhibition of DNA-dependent protein kinase catalytic subunit boosts rAAV transduction of polarized human airway epithelium

Adeno-associated virus 2.5T (AAV2.5T) was selected from the directed evolution of AAV capsid library in human airway epithelia. This study found that recombinant AAV2.5T (rAAV2.5T) transduction of well-differentiated primary human airway epithelia induced a DNA damage response (DDR) characterized by...

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Detalles Bibliográficos
Autores principales: Ning, Kang, Zhang, Xiujuan, Feng, Zehua, Hao, Siyuan, Kuz, Cagla Aksu, Cheng, Fang, Park, Soo Yuen, McFarlin, Shane, Engelhardt, John F., Yan, Ziying, Qiu, Jianming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568418/
https://www.ncbi.nlm.nih.gov/pubmed/37841417
http://dx.doi.org/10.1016/j.omtm.2023.101115

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