Dominant-negative HNF1α mutant promotes liver steatosis and inflammation by regulating hepatic complement factor D

Patients with HNF1A variants may develop liver steatosis, while the underlying mechanism is still unclear. Here, we established a mouse model carrying the dominant-negative HNF1α P291fsinsC mutation (hHNF1A(mut/-)) and found that the mutant mice developed liver steatosis spontaneously under the norm...

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Detalles Bibliográficos
Autores principales: Liu, Moke, Liu, Luna, Guo, Honglin, Fan, Xiude, Liu, Tianbao, Xu, Chao, He, Zhao, Song, Yongfeng, Gao, Ling, Shao, Shanshan, Zhao, Jiajun, Lu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568430/
https://www.ncbi.nlm.nih.gov/pubmed/37841581
http://dx.doi.org/10.1016/j.isci.2023.108018

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