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Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)

Nutritional deprivation occurring in most preterm infants postnatally can induce hyperglycemia, a significant and independent risk factor for suppressing physiological retinal vascularization (Phase I retinopathy of prematurity (ROP)), leading to compensatory but pathological neovascularization. Ami...

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Autores principales: Harman, Jarrod C., Pivodic, Aldina, Nilsson, Anders K., Boeck, Myriam, Yagi, Hitomi, Neilsen, Katherine, Ko, Minji, Yang, Jay, Kinter, Michael, Hellström, Ann, Fu, Zhongjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568433/
https://www.ncbi.nlm.nih.gov/pubmed/37841591
http://dx.doi.org/10.1016/j.isci.2023.108021
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author Harman, Jarrod C.
Pivodic, Aldina
Nilsson, Anders K.
Boeck, Myriam
Yagi, Hitomi
Neilsen, Katherine
Ko, Minji
Yang, Jay
Kinter, Michael
Hellström, Ann
Fu, Zhongjie
author_facet Harman, Jarrod C.
Pivodic, Aldina
Nilsson, Anders K.
Boeck, Myriam
Yagi, Hitomi
Neilsen, Katherine
Ko, Minji
Yang, Jay
Kinter, Michael
Hellström, Ann
Fu, Zhongjie
author_sort Harman, Jarrod C.
collection PubMed
description Nutritional deprivation occurring in most preterm infants postnatally can induce hyperglycemia, a significant and independent risk factor for suppressing physiological retinal vascularization (Phase I retinopathy of prematurity (ROP)), leading to compensatory but pathological neovascularization. Amino acid supplementation reduces retinal neovascularization in mice. Little is known about amino acid contribution to Phase I ROP. In mice modeling hyperglycemia-associated Phase I ROP, we found significant changes in retinal amino acids (including most decreased L-leucine, L-isoleucine, and L-valine). Parenteral L-isoleucine suppressed physiological retinal vascularization. In premature infants, severe ROP was associated with a higher mean intake of parenteral versus enteral amino acids in the first two weeks of life after adjustment for treatment group, gestational age at birth, birth weight, and sex. The number of days with parenteral amino acids support independently predicted severe ROP. Further understanding and modulating amino acids may help improve nutritional intervention and prevent Phase I ROP.
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spelling pubmed-105684332023-10-13 Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP) Harman, Jarrod C. Pivodic, Aldina Nilsson, Anders K. Boeck, Myriam Yagi, Hitomi Neilsen, Katherine Ko, Minji Yang, Jay Kinter, Michael Hellström, Ann Fu, Zhongjie iScience Article Nutritional deprivation occurring in most preterm infants postnatally can induce hyperglycemia, a significant and independent risk factor for suppressing physiological retinal vascularization (Phase I retinopathy of prematurity (ROP)), leading to compensatory but pathological neovascularization. Amino acid supplementation reduces retinal neovascularization in mice. Little is known about amino acid contribution to Phase I ROP. In mice modeling hyperglycemia-associated Phase I ROP, we found significant changes in retinal amino acids (including most decreased L-leucine, L-isoleucine, and L-valine). Parenteral L-isoleucine suppressed physiological retinal vascularization. In premature infants, severe ROP was associated with a higher mean intake of parenteral versus enteral amino acids in the first two weeks of life after adjustment for treatment group, gestational age at birth, birth weight, and sex. The number of days with parenteral amino acids support independently predicted severe ROP. Further understanding and modulating amino acids may help improve nutritional intervention and prevent Phase I ROP. Elsevier 2023-09-22 /pmc/articles/PMC10568433/ /pubmed/37841591 http://dx.doi.org/10.1016/j.isci.2023.108021 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Harman, Jarrod C.
Pivodic, Aldina
Nilsson, Anders K.
Boeck, Myriam
Yagi, Hitomi
Neilsen, Katherine
Ko, Minji
Yang, Jay
Kinter, Michael
Hellström, Ann
Fu, Zhongjie
Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)
title Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)
title_full Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)
title_fullStr Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)
title_full_unstemmed Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)
title_short Postnatal hyperglycemia alters amino acid profile in retinas (model of Phase I ROP)
title_sort postnatal hyperglycemia alters amino acid profile in retinas (model of phase i rop)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568433/
https://www.ncbi.nlm.nih.gov/pubmed/37841591
http://dx.doi.org/10.1016/j.isci.2023.108021
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