A pilot study of cerebral metabolism and serotonin 5-HT(2A) receptor occupancy in rats treated with the psychedelic tryptamine DMT in conjunction with the MAO inhibitor harmine

Rationale: The psychedelic effects of the traditional Amazonian botanical decoction known as ayahuasca are often attributed to agonism at brain serotonin 5-HT(2A) receptors by N,N-dimethyltryptamine (DMT). To reduce first pass metabolism of oral DMT, ayahuasca preparations additionally contain rever...

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Detalles Bibliográficos
Autores principales: Egger, Klemens, Gudmundsen, Frederik, Jessen, Naja Støckel, Baun, Christina, Poetzsch, Sandra N., Shalgunov, Vladimir, Herth, Matthias M., Quednow, Boris B., Martin-Soelch, Chantal, Dornbierer, Dario, Scheidegger, Milan, Cumming, Paul, Palner, Mikael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568461/
https://www.ncbi.nlm.nih.gov/pubmed/37841918
http://dx.doi.org/10.3389/fphar.2023.1140656

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