Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells (iPSCs) were differentiated to neuron, astrocyte, microglial, and endothelial cell fates. Loss of SORL1 leads...

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Detalles Bibliográficos
Autores principales: Lee, Hyo, Aylward, Aimee J., Pearse, Richard V., Lish, Alexandra M., Hsieh, Yi-Chen, Augur, Zachary M., Benoit, Courtney R., Chou, Vicky, Knupp, Allison, Pan, Cheryl, Goberdhan, Srilakshmi, Duong, Duc M., Seyfried, Nicholas T., Bennett, David A., Taga, Mariko F., Huynh, Kevin, Arnold, Matthias, Meikle, Peter J., Jager, Philip L. De, Menon, Vilas, Young, Jessica E., Young-Pearse, Tracy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568487/
https://www.ncbi.nlm.nih.gov/pubmed/37611586
http://dx.doi.org/10.1016/j.celrep.2023.112994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568487/
https://www.ncbi.nlm.nih.gov/pubmed/37611586
http://dx.doi.org/10.1016/j.celrep.2023.112994

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