Cargando…

Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer’s disease risk gene SORL1

SORL1 is implicated in the pathogenesis of Alzheimer’s disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells (iPSCs) were differentiated to neuron, astrocyte, microglial, and endothelial cell fates. Loss of SORL1 leads...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lee, Hyo, Aylward, Aimee J., Pearse, Richard V., Lish, Alexandra M., Hsieh, Yi-Chen, Augur, Zachary M., Benoit, Courtney R., Chou, Vicky, Knupp, Allison, Pan, Cheryl, Goberdhan, Srilakshmi, Duong, Duc M., Seyfried, Nicholas T., Bennett, David A., Taga, Mariko F., Huynh, Kevin, Arnold, Matthias, Meikle, Peter J., Jager, Philip L. De, Menon, Vilas, Young, Jessica E., Young-Pearse, Tracy L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568487/ https://www.ncbi.nlm.nih.gov/pubmed/37611586 http://dx.doi.org/10.1016/j.celrep.2023.112994

Ejemplares similares

INPP5D regulates inflammasome activation in human microglia
por: Chou, Vicky, et al.
Publicado: (2023)

The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons
por: Mishra, Swati, et al.
Publicado: (2022)

CluMan
por: Lopienski, Sebastian
Publicado: (2008)

Modulation of APOE and SORL1 genes on hippocampal functional connectivity in healthy young adults
por: Shen, Junlin, et al.
Publicado: (2017)

The combined risk effect among BIN1, CLU, and APOE genes in Alzheimer’s disease
por: dos Santos, Lígia Ramos, et al.
Publicado: (2020)

Assessment of Spontaneous Neuronal Activity In Vitro Using Multi-Well Multi-Electrode Arrays: Implications for Assay Development
por: Negri, Joseph, et al.
Publicado: (2020)

CluMan - Cluster management toolsuit
por: Siket, M, et al.
Publicado: (2010)

Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain
por: Grear, Karrie E, et al.
Publicado: (2009)

CLU blocks HDACI-mediated killing of neuroblastoma
por: Subramanian, Chitra, et al.
Publicado: (2010)

Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE
por: Wijsman, Ellen M., et al.
Publicado: (2011)

Rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer’s Disease in a Family with Several Generations of APOE-ɛ4 Homozygosity
por: Louwersheimer, Eva, et al.
Publicado: (2017)

CLU: A new algorithm for EST clustering
por: Ptitsyn, Andrey, et al.
Publicado: (2005)

Genetic Variability in CLU and Its Association with Alzheimer's Disease
por: Guerreiro, Rita J., et al.
Publicado: (2010)

Single-nucleotide polymorphisms of GSK3B, GAB2 and SORL1 in late-onset Alzheimer's disease: interactions with the APOE genotype
por: Izzo, Giselle, et al.
Publicado: (2013)

SORL1 Polymorphisms in Mexican Patients with Alzheimer’s Disease
por: Toral-Rios, Danira, et al.
Publicado: (2022)

SORL1 mutations in early- and late-onset Alzheimer disease
por: Cuccaro, Michael L., et al.
Publicado: (2016)

Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes
por: Schramm, Catherine, et al.
Publicado: (2022)

CLU Polymorphisms in Patients with Pseudoexfoliation Syndrome in Polish Population
por: Lesiewska, Hanna, et al.
Publicado: (2019)

Alternative Splicing Regulation of an Alzheimer’s Risk Variant in CLU
por: Han, Seonggyun, et al.
Publicado: (2020)

sCLU as prognostic biomarker and therapeutic target in osteosarcoma
por: Ma, Jinfeng, et al.
Publicado: (2019)

The SORL1 Gene and Convergent Neural Risk for Alzheimer's Disease Across the Human Lifespan
por: Felsky, Daniel, et al.
Publicado: (2013)

AliClu - Temporal sequence alignment for clustering longitudinal clinical data
por: Rama, Kishan, et al.
Publicado: (2019)

SORL1 mutation in a Greek family with Parkinson's disease and dementia
por: Xiromerisiou, Georgia, et al.
Publicado: (2021)

An Exploratory Study on CLU, CR1 and PICALM and Parkinson Disease
por: Gao, Jianjun, et al.
Publicado: (2011)

Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression
por: Srikanth, Priya, et al.
Publicado: (2018)

Publisher Correction: Penetrance estimation of Alzheimer disease in SORL1 loss-of-function variant carriers using a family-based strategy and stratification by APOE genotypes
por: Schramm, Catherine, et al.
Publicado: (2022)

A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency
por: Andersen, Olav M., et al.
Publicado: (2022)

Risk factor SORL1: from genetic association to functional validation in Alzheimer’s disease
por: Andersen, Olav M., et al.
Publicado: (2016)

Expression of an alternatively spliced variant of SORL1 in neuronal dendrites is decreased in patients with Alzheimer’s disease
por: Monti, Giulia, et al.
Publicado: (2021)

pVHL Mediates K63-Linked Ubiquitination of nCLU
por: Xue, Jing, et al.
Publicado: (2012)

CLU Genetic Variants and Cognitive Decline among Elderly and Oldest Old
por: Mengel-From, Jonas, et al.
Publicado: (2013)

Reduced secreted clusterin as a mechanism for Alzheimer-associated CLU mutations
por: Bettens, Karolien, et al.
Publicado: (2015)

sCLU regulates cisplatin chemosensitivity of lung cancer cells in vivo
por: Ma, Guoliang, et al.
Publicado: (2015)

BoCluSt: Bootstrap Clustering Stability Algorithm for Community Detection
por: Garcia, Carlos
Publicado: (2016)

Enhancement of conformational B-cell epitope prediction using CluSMOTE
por: Solihah, Binti, et al.
Publicado: (2020)

Elevated ganglioside GM2 activator (GM2A) in human brain tissue reduces neurite integrity and spontaneous neuronal activity
por: Hsieh, Yi-Chen, et al.
Publicado: (2022)

Impact of SORL1 genetic variations on MRI markers in non-demented elders
por: Yin, Rui-Hua, et al.
Publicado: (2016)

Nontoxic Targeting of Energy Metabolism in Preclinical VM-M3 Experimental Glioblastoma
por: Augur, Zachary M., et al.
Publicado: (2018)

A familial missense variant in the Alzheimer’s Disease gene SORL1 impairs its maturation and endosomal sorting
por: Fazeli, Elnaz, et al.
Publicado: (2023)

Influence of PICALM and CLU risk variants on beta EEG activity in Alzheimer’s disease patients
por: Maturana-Candelas, Aarón, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_69g67n0i38ofvg75tcoju9o2oa