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A review of the pathophysiology and the role of ion channels on bronchial asthma
Asthma is one of the main non-communicable chronic diseases and affects a huge portion of the population. It is a multifactorial disease, classified into several phenotypes, being the allergic the most frequent. The pathophysiological mechanism of asthma involves a Th2-type immune response, with hig...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568497/ https://www.ncbi.nlm.nih.gov/pubmed/37841931 http://dx.doi.org/10.3389/fphar.2023.1236550 |
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author | Figueiredo, Indyra Alencar Duarte Ferreira, Sarah Rebeca Dantas Fernandes, Jayne Muniz Silva, Bagnólia Araújo da Vasconcelos, Luiz Henrique César Cavalcante, Fabiana de Andrade |
author_facet | Figueiredo, Indyra Alencar Duarte Ferreira, Sarah Rebeca Dantas Fernandes, Jayne Muniz Silva, Bagnólia Araújo da Vasconcelos, Luiz Henrique César Cavalcante, Fabiana de Andrade |
author_sort | Figueiredo, Indyra Alencar Duarte |
collection | PubMed |
description | Asthma is one of the main non-communicable chronic diseases and affects a huge portion of the population. It is a multifactorial disease, classified into several phenotypes, being the allergic the most frequent. The pathophysiological mechanism of asthma involves a Th2-type immune response, with high concentrations of allergen-specific immunoglobulin E, eosinophilia, hyperreactivity and airway remodeling. These mechanisms are orchestrated by intracellular signaling from effector cells, such as lymphocytes and eosinophils. Ion channels play a fundamental role in maintaining the inflammatory response on asthma. In particular, transient receptor potential (TRP), stock-operated Ca(2+) channels (SOCs), Ca(2+)-activated K(+) channels (IK(Ca) and BK(Ca)), calcium-activated chloride channel (TMEM16A), cystic fibrosis transmembrane conductance regulator (CFTR), piezo-type mechanosensitive ion channel component 1 (PIEZO1) and purinergic P2X receptor (P2X). The recognition of the participation of these channels in the pathological process of asthma is important, as they become pharmacological targets for the discovery of new drugs and/or pharmacological tools that effectively help the pharmacotherapeutic follow-up of this disease, as well as the more specific mechanisms involved in worsening asthma. |
format | Online Article Text |
id | pubmed-10568497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105684972023-10-13 A review of the pathophysiology and the role of ion channels on bronchial asthma Figueiredo, Indyra Alencar Duarte Ferreira, Sarah Rebeca Dantas Fernandes, Jayne Muniz Silva, Bagnólia Araújo da Vasconcelos, Luiz Henrique César Cavalcante, Fabiana de Andrade Front Pharmacol Pharmacology Asthma is one of the main non-communicable chronic diseases and affects a huge portion of the population. It is a multifactorial disease, classified into several phenotypes, being the allergic the most frequent. The pathophysiological mechanism of asthma involves a Th2-type immune response, with high concentrations of allergen-specific immunoglobulin E, eosinophilia, hyperreactivity and airway remodeling. These mechanisms are orchestrated by intracellular signaling from effector cells, such as lymphocytes and eosinophils. Ion channels play a fundamental role in maintaining the inflammatory response on asthma. In particular, transient receptor potential (TRP), stock-operated Ca(2+) channels (SOCs), Ca(2+)-activated K(+) channels (IK(Ca) and BK(Ca)), calcium-activated chloride channel (TMEM16A), cystic fibrosis transmembrane conductance regulator (CFTR), piezo-type mechanosensitive ion channel component 1 (PIEZO1) and purinergic P2X receptor (P2X). The recognition of the participation of these channels in the pathological process of asthma is important, as they become pharmacological targets for the discovery of new drugs and/or pharmacological tools that effectively help the pharmacotherapeutic follow-up of this disease, as well as the more specific mechanisms involved in worsening asthma. Frontiers Media S.A. 2023-09-28 /pmc/articles/PMC10568497/ /pubmed/37841931 http://dx.doi.org/10.3389/fphar.2023.1236550 Text en Copyright © 2023 Figueiredo, Ferreira, Fernandes, Silva, Vasconcelos and Cavalcante. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Figueiredo, Indyra Alencar Duarte Ferreira, Sarah Rebeca Dantas Fernandes, Jayne Muniz Silva, Bagnólia Araújo da Vasconcelos, Luiz Henrique César Cavalcante, Fabiana de Andrade A review of the pathophysiology and the role of ion channels on bronchial asthma |
title | A review of the pathophysiology and the role of ion channels on bronchial asthma |
title_full | A review of the pathophysiology and the role of ion channels on bronchial asthma |
title_fullStr | A review of the pathophysiology and the role of ion channels on bronchial asthma |
title_full_unstemmed | A review of the pathophysiology and the role of ion channels on bronchial asthma |
title_short | A review of the pathophysiology and the role of ion channels on bronchial asthma |
title_sort | review of the pathophysiology and the role of ion channels on bronchial asthma |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568497/ https://www.ncbi.nlm.nih.gov/pubmed/37841931 http://dx.doi.org/10.3389/fphar.2023.1236550 |
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