Psychometric and next day electrodermal activity data from an experiment involving midazolam, ketamine, and painful stimulation

This is a report of unpublished data obtained from a randomized, single-blind, within-subject crossover design, neuroimaging trial comparing the effects of midazolam and ketamine on memory and pain. An experimental auditory paradigm paired with the periodic pain was used to examine auditory encoding and subsequent recognition. Psychometric surveys assessed stress, anxiety, depression, and pain behaviors. These data were collected to potentially characterize inter-subject variation during analysis. Electrodermal activity was measured to examine the association between previous pain-pairing of experimental items and autonomic responses during next day recognition memory testing, with exposure to the same auditory word items. Electrodermal responses were determined using an event-related analysis approach. These data may help shape future experiments using psychometric data to characterize individual responses or using next day electrodermal activity to determine conditioned responses to previously-experienced aversive stimuli.