Loss of carnitine palmitoyltransferase 1a reduces docosahexaenoic acid-containing phospholipids and drives sexually dimorphic liver disease in mice

BACKGROUND AND AIMS: Genome and epigenome wide association studies identified variants in carnitine palmitoyltransferase 1a (CPT1a) that associate with lipid traits. The goal of this study was to determine the role of liver-specific CPT1a on hepatic lipid metabolism. APPROACH AND RESULTS: Male and f...

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Detalles Bibliográficos
Autores principales: Zelows, Mikala M., Cady, Corissa, Dharanipragada, Nikitha, Mead, Anna E., Kipp, Zachary A., Bates, Evelyn A., Varadharajan, Venkateshwari, Banerjee, Rakhee, Park, Se-Hyung, Shelman, Nathan R., Clarke, Harrison A., Hawkinson, Tara R., Medina, Terrymar, Sun, Ramon C., Lydic, Todd A., Hinds, Terry D., Brown, J. Mark, Softic, Samir, Graf, Gregory A., Helsley, Robert N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568566/
https://www.ncbi.nlm.nih.gov/pubmed/37797918
http://dx.doi.org/10.1016/j.molmet.2023.101815

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