Cargando…

Utility of basal and peak TSH values in TRH stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism

In Japan, most neonates undergo screening for congenital hypothyroidism (CH). A TRH stimulation test (TRH-T) may be performed after initial treatment as a useful method for reevaluating the patient’s thyroid status. However, no studies have compared basal and peak TSH values in TRH-T in patients wit...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimura, Kazuhiro, Ikegawa, Kento, Hasegawa, Yukihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society for Pediatric Endocrinology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568572/
https://www.ncbi.nlm.nih.gov/pubmed/37842140
http://dx.doi.org/10.1297/cpe.2023-0020
_version_ 1785119381737439232
author Shimura, Kazuhiro
Ikegawa, Kento
Hasegawa, Yukihiro
author_facet Shimura, Kazuhiro
Ikegawa, Kento
Hasegawa, Yukihiro
author_sort Shimura, Kazuhiro
collection PubMed
description In Japan, most neonates undergo screening for congenital hypothyroidism (CH). A TRH stimulation test (TRH-T) may be performed after initial treatment as a useful method for reevaluating the patient’s thyroid status. However, no studies have compared basal and peak TSH values in TRH-T in patients with long-term follow-up. This was a retrospective and observational study. The inclusion criteria were as follows: (1) CH diagnosis based on positive newborn screening, (2) follow-up > 15 yr, and (3) TRH-T after LT4 discontinuation. The participants were divided into a no-treatment group (No-T group) and a treatment group (T group). The No-T and T groups included 14 and nine patients, respectively. The age at TRH-T was 5.38 yr for the No-T group and 4.25 yr for the T group, with no significant difference. The basal and peak TSH levels were significantly lower in the No-T group. The areas under the Receiver operating characteristic curve for basal and peak TSH values were 0.984 and 0.905, respectively. When the basal TSH level was under 4.594 IU/mL, the No-T group had a sensitivity of 1.00 and a specificity of 0.93. Basal TSH levels alone may be sufficient for predicting the long-term therapeutic prognosis of patients with CH.
format Online
Article
Text
id pubmed-10568572
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher The Japanese Society for Pediatric Endocrinology
record_format MEDLINE/PubMed
spelling pubmed-105685722023-10-13 Utility of basal and peak TSH values in TRH stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism Shimura, Kazuhiro Ikegawa, Kento Hasegawa, Yukihiro Clin Pediatr Endocrinol Original Article In Japan, most neonates undergo screening for congenital hypothyroidism (CH). A TRH stimulation test (TRH-T) may be performed after initial treatment as a useful method for reevaluating the patient’s thyroid status. However, no studies have compared basal and peak TSH values in TRH-T in patients with long-term follow-up. This was a retrospective and observational study. The inclusion criteria were as follows: (1) CH diagnosis based on positive newborn screening, (2) follow-up > 15 yr, and (3) TRH-T after LT4 discontinuation. The participants were divided into a no-treatment group (No-T group) and a treatment group (T group). The No-T and T groups included 14 and nine patients, respectively. The age at TRH-T was 5.38 yr for the No-T group and 4.25 yr for the T group, with no significant difference. The basal and peak TSH levels were significantly lower in the No-T group. The areas under the Receiver operating characteristic curve for basal and peak TSH values were 0.984 and 0.905, respectively. When the basal TSH level was under 4.594 IU/mL, the No-T group had a sensitivity of 1.00 and a specificity of 0.93. Basal TSH levels alone may be sufficient for predicting the long-term therapeutic prognosis of patients with CH. The Japanese Society for Pediatric Endocrinology 2023-06-23 2023 /pmc/articles/PMC10568572/ /pubmed/37842140 http://dx.doi.org/10.1297/cpe.2023-0020 Text en 2023©The Japanese Society for Pediatric Endocrinology https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ).
spellingShingle Original Article
Shimura, Kazuhiro
Ikegawa, Kento
Hasegawa, Yukihiro
Utility of basal and peak TSH values in TRH stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism
title Utility of basal and peak TSH values in TRH stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism
title_full Utility of basal and peak TSH values in TRH stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism
title_fullStr Utility of basal and peak TSH values in TRH stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism
title_full_unstemmed Utility of basal and peak TSH values in TRH stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism
title_short Utility of basal and peak TSH values in TRH stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism
title_sort utility of basal and peak tsh values in trh stimulation testing for predicting the long-term therapeutic prognosis of primary congenital hypothyroidism
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568572/
https://www.ncbi.nlm.nih.gov/pubmed/37842140
http://dx.doi.org/10.1297/cpe.2023-0020
work_keys_str_mv AT shimurakazuhiro utilityofbasalandpeaktshvaluesintrhstimulationtestingforpredictingthelongtermtherapeuticprognosisofprimarycongenitalhypothyroidism
AT ikegawakento utilityofbasalandpeaktshvaluesintrhstimulationtestingforpredictingthelongtermtherapeuticprognosisofprimarycongenitalhypothyroidism
AT hasegawayukihiro utilityofbasalandpeaktshvaluesintrhstimulationtestingforpredictingthelongtermtherapeuticprognosisofprimarycongenitalhypothyroidism