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Optimization of Metal Ion/Fuel Ratio for an Effective Combustion of Monticellite and Investigation of Its Microbial and Hemolytic Activity for Biomedical Applications

[Image: see text] Bioactive silicates have gained popularity as bone graft substitutes in recent years due to their exceptional ability to bind to host tissues. The current study investigates the effect of changing the metal ion-to-fuel ratio on the properties and biological activity of monticellite...

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Autores principales: Vijayakumar, Naveensubramaniam, Venkatraman, Senthil Kumar, Nandakumar, Ravindiran, Alex, Raveena Ann, Abraham, Jayanthi, Mohammadi, Hossein, Ebadi, Mona, Swamiappan, Sasikumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568587/
https://www.ncbi.nlm.nih.gov/pubmed/37841139
http://dx.doi.org/10.1021/acsomega.3c03984
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author Vijayakumar, Naveensubramaniam
Venkatraman, Senthil Kumar
Nandakumar, Ravindiran
Alex, Raveena Ann
Abraham, Jayanthi
Mohammadi, Hossein
Ebadi, Mona
Swamiappan, Sasikumar
author_facet Vijayakumar, Naveensubramaniam
Venkatraman, Senthil Kumar
Nandakumar, Ravindiran
Alex, Raveena Ann
Abraham, Jayanthi
Mohammadi, Hossein
Ebadi, Mona
Swamiappan, Sasikumar
author_sort Vijayakumar, Naveensubramaniam
collection PubMed
description [Image: see text] Bioactive silicates have gained popularity as bone graft substitutes in recent years due to their exceptional ability to bind to host tissues. The current study investigates the effect of changing the metal ion-to-fuel ratio on the properties and biological activity of monticellite prepared via the sol–gel connived combustion technique. Single-phasic monticellite was obtained at 900 °C, without any secondary-phase contaminants for the fuel-lean, stoichiometric, and fuel-rich conditions. SEM and TEM micrographs revealed the porous, spongy morphology of the materials. Because of the reduced crystallite size and higher surface area, the biomineralization of monticellite prepared under fuel-lean conditions resulted in more apatite deposition than those of the other two samples. The results show that the material has a good compressive strength comparable to natural bone, while its brittleness is equivalent to the lower moduli of bone. In terms of antibacterial and antifungal activities, the monticellite bioceramics outperformed the clinical pathogens. It can be used for bone tissue engineering and other biological applications due to its excellent anti-inflammatory and hemolysis inhibitory properties.
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spelling pubmed-105685872023-10-13 Optimization of Metal Ion/Fuel Ratio for an Effective Combustion of Monticellite and Investigation of Its Microbial and Hemolytic Activity for Biomedical Applications Vijayakumar, Naveensubramaniam Venkatraman, Senthil Kumar Nandakumar, Ravindiran Alex, Raveena Ann Abraham, Jayanthi Mohammadi, Hossein Ebadi, Mona Swamiappan, Sasikumar ACS Omega [Image: see text] Bioactive silicates have gained popularity as bone graft substitutes in recent years due to their exceptional ability to bind to host tissues. The current study investigates the effect of changing the metal ion-to-fuel ratio on the properties and biological activity of monticellite prepared via the sol–gel connived combustion technique. Single-phasic monticellite was obtained at 900 °C, without any secondary-phase contaminants for the fuel-lean, stoichiometric, and fuel-rich conditions. SEM and TEM micrographs revealed the porous, spongy morphology of the materials. Because of the reduced crystallite size and higher surface area, the biomineralization of monticellite prepared under fuel-lean conditions resulted in more apatite deposition than those of the other two samples. The results show that the material has a good compressive strength comparable to natural bone, while its brittleness is equivalent to the lower moduli of bone. In terms of antibacterial and antifungal activities, the monticellite bioceramics outperformed the clinical pathogens. It can be used for bone tissue engineering and other biological applications due to its excellent anti-inflammatory and hemolysis inhibitory properties. American Chemical Society 2023-09-26 /pmc/articles/PMC10568587/ /pubmed/37841139 http://dx.doi.org/10.1021/acsomega.3c03984 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Vijayakumar, Naveensubramaniam
Venkatraman, Senthil Kumar
Nandakumar, Ravindiran
Alex, Raveena Ann
Abraham, Jayanthi
Mohammadi, Hossein
Ebadi, Mona
Swamiappan, Sasikumar
Optimization of Metal Ion/Fuel Ratio for an Effective Combustion of Monticellite and Investigation of Its Microbial and Hemolytic Activity for Biomedical Applications
title Optimization of Metal Ion/Fuel Ratio for an Effective Combustion of Monticellite and Investigation of Its Microbial and Hemolytic Activity for Biomedical Applications
title_full Optimization of Metal Ion/Fuel Ratio for an Effective Combustion of Monticellite and Investigation of Its Microbial and Hemolytic Activity for Biomedical Applications
title_fullStr Optimization of Metal Ion/Fuel Ratio for an Effective Combustion of Monticellite and Investigation of Its Microbial and Hemolytic Activity for Biomedical Applications
title_full_unstemmed Optimization of Metal Ion/Fuel Ratio for an Effective Combustion of Monticellite and Investigation of Its Microbial and Hemolytic Activity for Biomedical Applications
title_short Optimization of Metal Ion/Fuel Ratio for an Effective Combustion of Monticellite and Investigation of Its Microbial and Hemolytic Activity for Biomedical Applications
title_sort optimization of metal ion/fuel ratio for an effective combustion of monticellite and investigation of its microbial and hemolytic activity for biomedical applications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568587/
https://www.ncbi.nlm.nih.gov/pubmed/37841139
http://dx.doi.org/10.1021/acsomega.3c03984
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