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Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers

BACKGROUND: The relationship between CSU and vaccines is reported in the literature. The post-vaccine clinical effect of COVİD-19 vaccines on CSU patients is still unclear. we aimed to evaluate clinical effects of COVID-19 Vaccines on CSU patients. MATERIALS AND METHODS: CSU patients under treatment...

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Autores principales: Kartal, Demet, Orujova, Shahzada, Ertaş, Ragıp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568618/
https://www.ncbi.nlm.nih.gov/pubmed/37841021
http://dx.doi.org/10.3389/fmed.2023.1222126
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author Kartal, Demet
Orujova, Shahzada
Ertaş, Ragıp
author_facet Kartal, Demet
Orujova, Shahzada
Ertaş, Ragıp
author_sort Kartal, Demet
collection PubMed
description BACKGROUND: The relationship between CSU and vaccines is reported in the literature. The post-vaccine clinical effect of COVİD-19 vaccines on CSU patients is still unclear. we aimed to evaluate clinical effects of COVID-19 Vaccines on CSU patients. MATERIALS AND METHODS: CSU patients under treatment and follow-up in our outpatient clinic were evaluated retrospectively. To determine disease activity the urticaria activity score over seven days (UAS7) was used. The details of demographic information, CSU treatment, history of COVID-19 infection and exacerbation of urticaria during infection, COVID-19 vaccinations, type of vaccine, side effect reaction time after vaccination, hospital admission requirement were also assessed. RESULTS: Total of 190 patients with a mean age of The mean age of patients was 41,7±14,0 years (range = 18–72) were enrooled. The patient sample consisted of 50 males and 140 females (male/female ratio 1:2.8). 181 (CoronaVac 77, Pfizer-BioNTech 104) patients were vaccinated. Urticarial exacerbation was occurred in 25 patients. The median UAS value was 5 before vaccination, it was 12 in patients with post-vaccine urticaria. Two patients had angioedema and one patient had anaphylaxis after vaccinated with Pfizer-BioNTech. CONCLUSION: COVID-19 vaccination in the CSU can be considered safe. Cases with urticarial exacerbation appear to be transient and can be managed by antihistamine and/or systemic steroid therapies. More extensive studies are needed for the relationship with CSU and post-coronavirus vaccination anaphylaxy.
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spelling pubmed-105686182023-10-13 Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers Kartal, Demet Orujova, Shahzada Ertaş, Ragıp Front Med (Lausanne) Medicine BACKGROUND: The relationship between CSU and vaccines is reported in the literature. The post-vaccine clinical effect of COVİD-19 vaccines on CSU patients is still unclear. we aimed to evaluate clinical effects of COVID-19 Vaccines on CSU patients. MATERIALS AND METHODS: CSU patients under treatment and follow-up in our outpatient clinic were evaluated retrospectively. To determine disease activity the urticaria activity score over seven days (UAS7) was used. The details of demographic information, CSU treatment, history of COVID-19 infection and exacerbation of urticaria during infection, COVID-19 vaccinations, type of vaccine, side effect reaction time after vaccination, hospital admission requirement were also assessed. RESULTS: Total of 190 patients with a mean age of The mean age of patients was 41,7±14,0 years (range = 18–72) were enrooled. The patient sample consisted of 50 males and 140 females (male/female ratio 1:2.8). 181 (CoronaVac 77, Pfizer-BioNTech 104) patients were vaccinated. Urticarial exacerbation was occurred in 25 patients. The median UAS value was 5 before vaccination, it was 12 in patients with post-vaccine urticaria. Two patients had angioedema and one patient had anaphylaxis after vaccinated with Pfizer-BioNTech. CONCLUSION: COVID-19 vaccination in the CSU can be considered safe. Cases with urticarial exacerbation appear to be transient and can be managed by antihistamine and/or systemic steroid therapies. More extensive studies are needed for the relationship with CSU and post-coronavirus vaccination anaphylaxy. Frontiers Media S.A. 2023-09-28 /pmc/articles/PMC10568618/ /pubmed/37841021 http://dx.doi.org/10.3389/fmed.2023.1222126 Text en Copyright © 2023 Kartal, Orujova and Ertaş. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Kartal, Demet
Orujova, Shahzada
Ertaş, Ragıp
Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers
title Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers
title_full Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers
title_fullStr Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers
title_full_unstemmed Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers
title_short Clinical effects of COVID-19 vaccines on chronic spontaneous urticaria patients: a study on two Turkish centers
title_sort clinical effects of covid-19 vaccines on chronic spontaneous urticaria patients: a study on two turkish centers
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568618/
https://www.ncbi.nlm.nih.gov/pubmed/37841021
http://dx.doi.org/10.3389/fmed.2023.1222126
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