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Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens

With the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts. Nicotine increases the release of dopamine (DA) into the nucleus accumbens (NAc), causing feelings of satisfaction. However, the dif...

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Autores principales: Li, Xiaonan, Lu, Lehua, He, Ying, Zhang, Hui, Zhang, Yihui, Sheng, Huaquan, Chen, Ming, Ru, Jiexiong, Gao, Yihan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568619/
https://www.ncbi.nlm.nih.gov/pubmed/37841907
http://dx.doi.org/10.3389/fphar.2023.1279512
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author Li, Xiaonan
Lu, Lehua
He, Ying
Zhang, Hui
Zhang, Yihui
Sheng, Huaquan
Chen, Ming
Ru, Jiexiong
Gao, Yihan
author_facet Li, Xiaonan
Lu, Lehua
He, Ying
Zhang, Hui
Zhang, Yihui
Sheng, Huaquan
Chen, Ming
Ru, Jiexiong
Gao, Yihan
author_sort Li, Xiaonan
collection PubMed
description With the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts. Nicotine increases the release of dopamine (DA) into the nucleus accumbens (NAc), causing feelings of satisfaction. However, the differences in the DA-increasing effects of different nicotine salts have not been reported. In this study, we used a G protein-coupled receptor-activated DA fluorescent probe (GRABDA1m) and optical fiber photometric recording equipment to monitor the dynamic changes and kinetics of DA release in the NAc of mice exposed to different e-cigarette aerosols, including nicotine, nicotine benzoate, nicotine tartrate, nicotine lactate, nicotine levulinic acid, nicotine malate, and nicotine citrate. The results of this study were as follows: 1) Different types of nicotine salts could increase the release of DA in the NAc. 2) The slopes and half-effective concentrations of the fitted curves were different, suggesting that each nicotine salt had a difference in the efficiency of increasing DA release with concentration changes. 3) The absorption rates of different nicotine salts containing the same original nicotine concentration were significantly different by measuring the blood nicotine content. The effect of nicotine salts on increasing DA was directly proportional to the blood nicotine level. In conclusion, by observing the effects of nicotine salts on DA release in real time in vivo, differences in the pharmacological effects of nicotine salts are revealed to better understand the mechanism underlying the regulatory effects of nicotine salts on the brain.
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spelling pubmed-105686192023-10-13 Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens Li, Xiaonan Lu, Lehua He, Ying Zhang, Hui Zhang, Yihui Sheng, Huaquan Chen, Ming Ru, Jiexiong Gao, Yihan Front Pharmacol Pharmacology With the growing number of individuals regularly using e-cigarettes, it has become increasingly important to understand the psychobiological effects of nicotine salts. Nicotine increases the release of dopamine (DA) into the nucleus accumbens (NAc), causing feelings of satisfaction. However, the differences in the DA-increasing effects of different nicotine salts have not been reported. In this study, we used a G protein-coupled receptor-activated DA fluorescent probe (GRABDA1m) and optical fiber photometric recording equipment to monitor the dynamic changes and kinetics of DA release in the NAc of mice exposed to different e-cigarette aerosols, including nicotine, nicotine benzoate, nicotine tartrate, nicotine lactate, nicotine levulinic acid, nicotine malate, and nicotine citrate. The results of this study were as follows: 1) Different types of nicotine salts could increase the release of DA in the NAc. 2) The slopes and half-effective concentrations of the fitted curves were different, suggesting that each nicotine salt had a difference in the efficiency of increasing DA release with concentration changes. 3) The absorption rates of different nicotine salts containing the same original nicotine concentration were significantly different by measuring the blood nicotine content. The effect of nicotine salts on increasing DA was directly proportional to the blood nicotine level. In conclusion, by observing the effects of nicotine salts on DA release in real time in vivo, differences in the pharmacological effects of nicotine salts are revealed to better understand the mechanism underlying the regulatory effects of nicotine salts on the brain. Frontiers Media S.A. 2023-09-28 /pmc/articles/PMC10568619/ /pubmed/37841907 http://dx.doi.org/10.3389/fphar.2023.1279512 Text en Copyright © 2023 Li, Lu, He, Zhang, Zhang, Sheng, Chen, Ru and Gao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Li, Xiaonan
Lu, Lehua
He, Ying
Zhang, Hui
Zhang, Yihui
Sheng, Huaquan
Chen, Ming
Ru, Jiexiong
Gao, Yihan
Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
title Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
title_full Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
title_fullStr Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
title_full_unstemmed Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
title_short Pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
title_sort pharmacological effects of nicotine salts on dopamine release in the nucleus accumbens
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568619/
https://www.ncbi.nlm.nih.gov/pubmed/37841907
http://dx.doi.org/10.3389/fphar.2023.1279512
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