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Comparison of Safety of Leadless Pacemakers and Transvenous Pacemakers: A Meta-Analysis

Pacemakers have been accessible for six decades, and clearly defined criteria for pacemaker implantation have been established. Within the contemporary clinical practice, two dependable pacing platforms exist leadless pacemakers and transvenous pacemakers. The aim of this meta-analysis is to compare...

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Autores principales: Gangannapalle, Mahesh, Monday, Obinna, Rawat, Anurag, Nwoko, Ugonna A, Mandal, Arun Kumar, Babur, Maham, Khan, Tayyaba J, Palleti, Sujith K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568652/
https://www.ncbi.nlm.nih.gov/pubmed/37842352
http://dx.doi.org/10.7759/cureus.45086
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author Gangannapalle, Mahesh
Monday, Obinna
Rawat, Anurag
Nwoko, Ugonna A
Mandal, Arun Kumar
Babur, Maham
Khan, Tayyaba J
Palleti, Sujith K
author_facet Gangannapalle, Mahesh
Monday, Obinna
Rawat, Anurag
Nwoko, Ugonna A
Mandal, Arun Kumar
Babur, Maham
Khan, Tayyaba J
Palleti, Sujith K
author_sort Gangannapalle, Mahesh
collection PubMed
description Pacemakers have been accessible for six decades, and clearly defined criteria for pacemaker implantation have been established. Within the contemporary clinical practice, two dependable pacing platforms exist leadless pacemakers and transvenous pacemakers. The aim of this meta-analysis is to compare the safety of leadless pacemakers to transvenous pacemakers. This meta-analysis adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 framework. A comprehensive and systematic search was conducted across various databases including Scopus, Cochrane Library, and EMBASE, spanning from inception to August 15, 2023. The primary outcomes assessed in this meta-analysis were total complications, all-cause mortality, and device-related complications. Furthermore, secondary outcomes evaluated encompassed the need for reintervention, occurrences of pneumothorax, pericardial effusion, endocarditis, hemothorax, and hematoma. Total 17 studies were included in this meta-analysis. The findings of this study showed that patients with leadless pacemakers had a lower risk of total complications, device-related complications, pneumothorax, and endocarditis. The risk of reintervention was significantly lower in the leadless pacemaker group. However, compared to a transvenous pacemaker, the risk of pericardial effusion was significantly higher in the leadless pacemaker group. It is important to acknowledge the limitations arising from the lack of extensive long-term follow-up data for leadless pacemakers. As technology evolves, continued research will be essential in uncovering the full spectrum of prolonged complications associated with these devices.
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spelling pubmed-105686522023-10-13 Comparison of Safety of Leadless Pacemakers and Transvenous Pacemakers: A Meta-Analysis Gangannapalle, Mahesh Monday, Obinna Rawat, Anurag Nwoko, Ugonna A Mandal, Arun Kumar Babur, Maham Khan, Tayyaba J Palleti, Sujith K Cureus Cardiology Pacemakers have been accessible for six decades, and clearly defined criteria for pacemaker implantation have been established. Within the contemporary clinical practice, two dependable pacing platforms exist leadless pacemakers and transvenous pacemakers. The aim of this meta-analysis is to compare the safety of leadless pacemakers to transvenous pacemakers. This meta-analysis adhered to the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 framework. A comprehensive and systematic search was conducted across various databases including Scopus, Cochrane Library, and EMBASE, spanning from inception to August 15, 2023. The primary outcomes assessed in this meta-analysis were total complications, all-cause mortality, and device-related complications. Furthermore, secondary outcomes evaluated encompassed the need for reintervention, occurrences of pneumothorax, pericardial effusion, endocarditis, hemothorax, and hematoma. Total 17 studies were included in this meta-analysis. The findings of this study showed that patients with leadless pacemakers had a lower risk of total complications, device-related complications, pneumothorax, and endocarditis. The risk of reintervention was significantly lower in the leadless pacemaker group. However, compared to a transvenous pacemaker, the risk of pericardial effusion was significantly higher in the leadless pacemaker group. It is important to acknowledge the limitations arising from the lack of extensive long-term follow-up data for leadless pacemakers. As technology evolves, continued research will be essential in uncovering the full spectrum of prolonged complications associated with these devices. Cureus 2023-09-12 /pmc/articles/PMC10568652/ /pubmed/37842352 http://dx.doi.org/10.7759/cureus.45086 Text en Copyright © 2023, Gangannapalle et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Cardiology
Gangannapalle, Mahesh
Monday, Obinna
Rawat, Anurag
Nwoko, Ugonna A
Mandal, Arun Kumar
Babur, Maham
Khan, Tayyaba J
Palleti, Sujith K
Comparison of Safety of Leadless Pacemakers and Transvenous Pacemakers: A Meta-Analysis
title Comparison of Safety of Leadless Pacemakers and Transvenous Pacemakers: A Meta-Analysis
title_full Comparison of Safety of Leadless Pacemakers and Transvenous Pacemakers: A Meta-Analysis
title_fullStr Comparison of Safety of Leadless Pacemakers and Transvenous Pacemakers: A Meta-Analysis
title_full_unstemmed Comparison of Safety of Leadless Pacemakers and Transvenous Pacemakers: A Meta-Analysis
title_short Comparison of Safety of Leadless Pacemakers and Transvenous Pacemakers: A Meta-Analysis
title_sort comparison of safety of leadless pacemakers and transvenous pacemakers: a meta-analysis
topic Cardiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568652/
https://www.ncbi.nlm.nih.gov/pubmed/37842352
http://dx.doi.org/10.7759/cureus.45086
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