Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin

[Image: see text] Glycomonomers having N-glycosidic linkages were prepared from a known glycosyl amine, N-acetyl-d-glucosamine (GlcNAc). Radical polymerization of the glycomonomers gave a series of glycopolymers displaying various sugar densities, which were models of the core structure of Asn-linke...

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Detalles Bibliográficos
Autores principales: Matsushita, Takahiko, Nozaki, Momoka, Sunaga, Mio, Koyama, Tetsuo, Hatano, Ken, Matsuoka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568714/
https://www.ncbi.nlm.nih.gov/pubmed/37841120
http://dx.doi.org/10.1021/acsomega.3c05151
Descripción
Sumario:[Image: see text] Glycomonomers having N-glycosidic linkages were prepared from a known glycosyl amine, N-acetyl-d-glucosamine (GlcNAc). Radical polymerization of the glycomonomers gave a series of glycopolymers displaying various sugar densities, which were models of the core structure of Asn-linked-type glycoproteins. In addition, fluorometric analyses of wheat germ agglutinin (WGA) against the glycopolymers were carried out, and the results showed unique binding specificities on the basis of flexibility of sugar moieties.

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