Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin

[Image: see text] Glycomonomers having N-glycosidic linkages were prepared from a known glycosyl amine, N-acetyl-d-glucosamine (GlcNAc). Radical polymerization of the glycomonomers gave a series of glycopolymers displaying various sugar densities, which were models of the core structure of Asn-linke...

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Autores principales: Matsushita, Takahiko, Nozaki, Momoka, Sunaga, Mio, Koyama, Tetsuo, Hatano, Ken, Matsuoka, Koji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568714/
https://www.ncbi.nlm.nih.gov/pubmed/37841120
http://dx.doi.org/10.1021/acsomega.3c05151
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author Matsushita, Takahiko
Nozaki, Momoka
Sunaga, Mio
Koyama, Tetsuo
Hatano, Ken
Matsuoka, Koji
author_facet Matsushita, Takahiko
Nozaki, Momoka
Sunaga, Mio
Koyama, Tetsuo
Hatano, Ken
Matsuoka, Koji
author_sort Matsushita, Takahiko
collection PubMed
description [Image: see text] Glycomonomers having N-glycosidic linkages were prepared from a known glycosyl amine, N-acetyl-d-glucosamine (GlcNAc). Radical polymerization of the glycomonomers gave a series of glycopolymers displaying various sugar densities, which were models of the core structure of Asn-linked-type glycoproteins. In addition, fluorometric analyses of wheat germ agglutinin (WGA) against the glycopolymers were carried out, and the results showed unique binding specificities on the basis of flexibility of sugar moieties.
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spelling pubmed-105687142023-10-13 Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin Matsushita, Takahiko Nozaki, Momoka Sunaga, Mio Koyama, Tetsuo Hatano, Ken Matsuoka, Koji ACS Omega [Image: see text] Glycomonomers having N-glycosidic linkages were prepared from a known glycosyl amine, N-acetyl-d-glucosamine (GlcNAc). Radical polymerization of the glycomonomers gave a series of glycopolymers displaying various sugar densities, which were models of the core structure of Asn-linked-type glycoproteins. In addition, fluorometric analyses of wheat germ agglutinin (WGA) against the glycopolymers were carried out, and the results showed unique binding specificities on the basis of flexibility of sugar moieties. American Chemical Society 2023-09-26 /pmc/articles/PMC10568714/ /pubmed/37841120 http://dx.doi.org/10.1021/acsomega.3c05151 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Matsushita, Takahiko
Nozaki, Momoka
Sunaga, Mio
Koyama, Tetsuo
Hatano, Ken
Matsuoka, Koji
Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin
title Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin
title_full Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin
title_fullStr Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin
title_full_unstemmed Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin
title_short Preparation of N-Linked-Type GlcNAc Monomers for Glycopolymers and Binding Specificity for Lectin
title_sort preparation of n-linked-type glcnac monomers for glycopolymers and binding specificity for lectin
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568714/
https://www.ncbi.nlm.nih.gov/pubmed/37841120
http://dx.doi.org/10.1021/acsomega.3c05151
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