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Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics
Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological characteristics, including astrocytomas, oligodendrogliomas, glioblastoma multiforme (GBM), and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568859/ https://www.ncbi.nlm.nih.gov/pubmed/37821870 http://dx.doi.org/10.1186/s12935-023-03090-7 |
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author | Tabnak, Peyman Hasanzade Bashkandi, Aysa Ebrahimnezhad, Mohammad Soleimani, Mahdieh |
author_facet | Tabnak, Peyman Hasanzade Bashkandi, Aysa Ebrahimnezhad, Mohammad Soleimani, Mahdieh |
author_sort | Tabnak, Peyman |
collection | PubMed |
description | Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological characteristics, including astrocytomas, oligodendrogliomas, glioblastoma multiforme (GBM), and mixed tumors. The forkhead box (FOX) transcription factors comprise a collection of proteins that play various roles in numerous complex molecular cascades and have been discovered to be differentially expressed in distinct glioma subtypes. FOXM1 and FOXOs have been recognized as crucial transcription factors in tumor cells, including glioma cells. Accumulating data indicates that FOXM1 acts as an oncogene in various types of cancers, and a significant part of studies has investigated its function in glioma. Although recent studies considered FOXO subgroups as tumor suppressors, there are pieces of evidence that they may have an oncogenic role. This review will discuss the subtle functions of FOXOs and FOXM1 in gliomas, dissecting their regulatory network with other proteins, microRNAs and their role in glioma progression, including stem cell differentiation and therapy resistance/sensitivity, alongside highlighting recent pharmacological progress for modulating their expression. |
format | Online Article Text |
id | pubmed-10568859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-105688592023-10-13 Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics Tabnak, Peyman Hasanzade Bashkandi, Aysa Ebrahimnezhad, Mohammad Soleimani, Mahdieh Cancer Cell Int Review Glioma is the most aggressive and malignant type of primary brain tumor, comprises the majority of central nervous system deaths, and is categorized into different subgroups according to its histological characteristics, including astrocytomas, oligodendrogliomas, glioblastoma multiforme (GBM), and mixed tumors. The forkhead box (FOX) transcription factors comprise a collection of proteins that play various roles in numerous complex molecular cascades and have been discovered to be differentially expressed in distinct glioma subtypes. FOXM1 and FOXOs have been recognized as crucial transcription factors in tumor cells, including glioma cells. Accumulating data indicates that FOXM1 acts as an oncogene in various types of cancers, and a significant part of studies has investigated its function in glioma. Although recent studies considered FOXO subgroups as tumor suppressors, there are pieces of evidence that they may have an oncogenic role. This review will discuss the subtle functions of FOXOs and FOXM1 in gliomas, dissecting their regulatory network with other proteins, microRNAs and their role in glioma progression, including stem cell differentiation and therapy resistance/sensitivity, alongside highlighting recent pharmacological progress for modulating their expression. BioMed Central 2023-10-11 /pmc/articles/PMC10568859/ /pubmed/37821870 http://dx.doi.org/10.1186/s12935-023-03090-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Tabnak, Peyman Hasanzade Bashkandi, Aysa Ebrahimnezhad, Mohammad Soleimani, Mahdieh Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics |
title | Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics |
title_full | Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics |
title_fullStr | Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics |
title_full_unstemmed | Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics |
title_short | Forkhead box transcription factors (FOXOs and FOXM1) in glioma: from molecular mechanisms to therapeutics |
title_sort | forkhead box transcription factors (foxos and foxm1) in glioma: from molecular mechanisms to therapeutics |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568859/ https://www.ncbi.nlm.nih.gov/pubmed/37821870 http://dx.doi.org/10.1186/s12935-023-03090-7 |
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