Cardiac glycoside ouabain efficiently targets leukemic stem cell apoptotic machinery independent of cell differentiation status

BACKGROUND: Acute myeloid leukemia (AML) is an aggressive hematologic malignancy characterized by an accumulation of immature leukemic myeloblasts initiating from leukemic stem cells (LSCs)—the subpopulation that is also considered the root cause of chemotherapy resistance. Repurposing cardiac glyco...

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Detalles Bibliográficos
Autores principales: Poohadsuan, Jirarat, O’Doherty, George A., Owattanapanich, Weerapat, Kungwankiattichai, Smith, Rojanasakul, Yon, Issaragrisil, Surapol, Luanpitpong, Sudjit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568939/
https://www.ncbi.nlm.nih.gov/pubmed/37828578
http://dx.doi.org/10.1186/s12964-023-01317-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568939/
https://www.ncbi.nlm.nih.gov/pubmed/37828578
http://dx.doi.org/10.1186/s12964-023-01317-8

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