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Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite
BACKGROUND AND PURPOSE: The present study aimed to obtain a taste-masked oral disintegrating tablet (ODT) containing tolterodine tartrate (TT) intercalated into montmorillonite (MMT) EXPERIMENTAL APPROACH: The TT-MMT hybrid was prepared by ion exchange reaction. The effect of the initial concentrati...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568959/ https://www.ncbi.nlm.nih.gov/pubmed/37842521 http://dx.doi.org/10.4103/1735-5362.383708 |
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author | Taymouri, Somayeh Mostafavi, Abolfazl Talabaki, Homa |
author_facet | Taymouri, Somayeh Mostafavi, Abolfazl Talabaki, Homa |
author_sort | Taymouri, Somayeh |
collection | PubMed |
description | BACKGROUND AND PURPOSE: The present study aimed to obtain a taste-masked oral disintegrating tablet (ODT) containing tolterodine tartrate (TT) intercalated into montmorillonite (MMT) EXPERIMENTAL APPROACH: The TT-MMT hybrid was prepared by ion exchange reaction. The effect of the initial concentration of TT, MMT, temperature, and pH on the encapsulation efficiency (EE) % of the drug in MMT was evaluated. The selected TT-MMT hybrid was characterized by X-ray diffraction (XRD), Fourier transforms infrared (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Then, the optimized TT-MMT hybrid was incorporated in the ODT prepared by direct compression method and taste-masking assessment performed by a human test panel. FINDINGS/RESULTS: The EE% of TT was in the range of 22.67 to 71.06% in different formulations. It was found that increases in MMT concentration significantly increased EE%. DSC and XRD studies indicated that the TT was intercalated in the MMT interlayer space in an amorphous or molecular state. In-vitro release studies at pH 6.8 showed that the amount of the drug released from the TT-MMT hybrid was negligible for the first 3 min. The post-compression of ODT also showed satisfactory results in terms of friability, hardness, disintegration time, and taste. CONCLUSION AND IMPLICATIONS: MMT-ODT could be a suitable vehicle for the taste masking of TT, with the potential for use in patients with swallowing problems. |
format | Online Article Text |
id | pubmed-10568959 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-105689592023-10-13 Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite Taymouri, Somayeh Mostafavi, Abolfazl Talabaki, Homa Res Pharm Sci Original Article BACKGROUND AND PURPOSE: The present study aimed to obtain a taste-masked oral disintegrating tablet (ODT) containing tolterodine tartrate (TT) intercalated into montmorillonite (MMT) EXPERIMENTAL APPROACH: The TT-MMT hybrid was prepared by ion exchange reaction. The effect of the initial concentration of TT, MMT, temperature, and pH on the encapsulation efficiency (EE) % of the drug in MMT was evaluated. The selected TT-MMT hybrid was characterized by X-ray diffraction (XRD), Fourier transforms infrared (FTIR), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM). Then, the optimized TT-MMT hybrid was incorporated in the ODT prepared by direct compression method and taste-masking assessment performed by a human test panel. FINDINGS/RESULTS: The EE% of TT was in the range of 22.67 to 71.06% in different formulations. It was found that increases in MMT concentration significantly increased EE%. DSC and XRD studies indicated that the TT was intercalated in the MMT interlayer space in an amorphous or molecular state. In-vitro release studies at pH 6.8 showed that the amount of the drug released from the TT-MMT hybrid was negligible for the first 3 min. The post-compression of ODT also showed satisfactory results in terms of friability, hardness, disintegration time, and taste. CONCLUSION AND IMPLICATIONS: MMT-ODT could be a suitable vehicle for the taste masking of TT, with the potential for use in patients with swallowing problems. Medknow Publications & Media Pvt Ltd 2023-08-20 /pmc/articles/PMC10568959/ /pubmed/37842521 http://dx.doi.org/10.4103/1735-5362.383708 Text en Copyright: © 2023 Research in Pharmaceutical Sciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Taymouri, Somayeh Mostafavi, Abolfazl Talabaki, Homa Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite |
title | Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite |
title_full | Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite |
title_fullStr | Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite |
title_full_unstemmed | Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite |
title_short | Formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite |
title_sort | formulation and evaluation of taste-masked oral disintegrating tablet containing tolterodine-loaded montmorillonite |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10568959/ https://www.ncbi.nlm.nih.gov/pubmed/37842521 http://dx.doi.org/10.4103/1735-5362.383708 |
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