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Characterization of tigurilysin, a novel human CD59-specific cholesterol-dependent cytolysin, reveals a role for host specificity in augmenting toxin activity

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Cholesterol-dependent cytolysins (CDCs) are a large family of pore-forming toxins, produced by numerous Gram-positive pathogens. CDCs depend on host membrane cholesterol for pore formation; some CDCs also require surface-associated human CD59 (hCD59) for binding, conferring specificity for human cel...

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Detalles Bibliográficos
Autores principales:	Shahi, Ifrah, Dongas, Sophia A., Ilmain, Juliana K., Torres, Victor J., Ratner, Adam J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Microbiology Society 2023
Materias:	Microbial Virulence and Pathogenesis
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569062/ https://www.ncbi.nlm.nih.gov/pubmed/37702594 http://dx.doi.org/10.1099/mic.0.001393

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