Cargando…

Dose-sparing effect of lapatinib co-administered with a high-fat enteral nutrition emulsion: preclinical pharmacokinetic study

BACKGROUND: Lapatinib is an oral small-molecule tyrosine kinase inhibitor indicated for advanced or metastatic HER2-positive breast cancer. In order to reduce the treatment cost, a high-fat enteral nutrition emulsion TPF-T was selected as a dose-sparing agent for lapatinib-based therapies. This stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Junfeng, Xu, Gaoqi, Yang, Dihong, Song, Yu, Tong, Yinghui, Kong, Sisi, Ding, Haiying, Fang, Luo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2023
Materias:	Drugs and Devices
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569162/ https://www.ncbi.nlm.nih.gov/pubmed/37842056 http://dx.doi.org/10.7717/peerj.16207

Ejemplares similares

Development and validation of bioimpedance prediction equations for fat-free mass in unilateral male amputees
por: Choi, Hyuk-Jae, et al.
Publicado: (2021)

A simple equation to estimate body fat percentage in children with overweightness or obesity: a retrospective study
por: Cortés-Castell, Ernesto, et al.
Publicado: (2017)

Simultaneous determination of two galangin metabolites from Alpinia Officinarum Hance in rat plasma by UF LC-MS/MS and its application in pharmacokinetics study
por: Liu, Rangru, et al.
Publicado: (2021)

The preventive effect of dexmedetomidine on paroxysmal sympathetic hyperactivity in severe traumatic brain injury patients who have undergone surgery: a retrospective study
por: Tang, Qilin, et al.
Publicado: (2017)

Preclinical evaluation of efficacy and pharmacokinetics of gentamicin containing extracellular‐matrix envelope
por: Sohail, M. Rizwan, et al.
Publicado: (2020)

Comparative proteinuria management of different angiotensin-converting enzyme inhibitors or angiotensin receptor blockers for normotensive patients with CKD: a Bayesian network meta-analysis
por: Ye, Huizhen, et al.
Publicado: (2020)

ABC transporters P-gp and Bcrp do not limit the brain uptake of the novel antipsychotic and anticonvulsant drug cannabidiol in mice
por: Brzozowska, Natalia, et al.
Publicado: (2016)

Retrospective cohort study of anti-tumor necrosis factor agent use in a veteran population
por: Bounthavong, Mark, et al.
Publicado: (2014)

Swedish high-school pupils’ attitudes towards drugs in relation to drug usage, impulsiveness and other risk factors
por: Mousavi, Fariba, et al.
Publicado: (2014)

Prescribing of psychotropic medications to the elderly population of a Canadian province: a retrospective study using administrative databases
por: Alessi-Severini, Silvia, et al.
Publicado: (2013)

Drug delivery systems for ovarian cancer treatment: a systematic review and meta-analysis of animal studies
por: Raavé, René, et al.
Publicado: (2015)

Epidemiological evidence on extra-medical use of prescription pain relievers: transitions from newly incident use to dependence among 12–21 year olds in the United States using meta-analysis, 2002–13
por: Parker, Maria A., et al.
Publicado: (2015)

Adverse events associated with incretin-based drugs in Japanese spontaneous reports: a mixed effects logistic regression model
por: Narushima, Daichi, et al.
Publicado: (2016)

Dramatyping: a generic algorithm for detecting reasonable temporal correlations between drug administration and lab value alterations
por: Newe, Axel
Publicado: (2016)

Test re-test reliability and construct validity of the star-track test of manual dexterity
por: Kildebro, Niels, et al.
Publicado: (2015)

Performance, usability and comparison of two versions of a new macular vision test: the handheld Radial Shape Discrimination test
por: Ku, Jae Y., et al.
Publicado: (2016)

Fuel-cell breathalyser use for field research on alcohol intoxication: an independent psychometric evaluation
por: Sorbello, Jacob G., et al.
Publicado: (2018)

Stability of an ophthalmic formulation of polyhexamethylene biguanide in gamma-sterilized and ethylene oxide sterilized low density polyethylene multidose eyedroppers
por: Bouattour, Yassine, et al.
Publicado: (2018)

Repercussion of nonsteroidal anti-inflammatory drugs on the gene expression of human osteoblasts
por: Melguizo-Rodríguez, Lucia, et al.
Publicado: (2018)

Pentoxifylline decreases post-operative intra-abdominal adhesion formation in an animal model
por: Yang, Ya-Lin, et al.
Publicado: (2018)

Investigating the level of agreement of two positioning protocols when using dual energy X-ray absorptiometry in the assessment of body composition
por: Shiel, Flinn, et al.
Publicado: (2017)

When, why and how foot orthoses (FOs) should be prescribed for children with flexible pes planus: a Delphi survey of podiatrists
por: Dars, Sindhrani, et al.
Publicado: (2018)

Introducing Vernakalant into Clinical Practice
por: Hall, Angela JM, et al.
Publicado: (2019)

Young, American Indian or Alaskan Native, and born in the USA: at excess risk of starting extra-medical prescription pain reliever use?
por: Parker, Maria A., et al.
Publicado: (2018)

Building interpretable models for polypharmacy prediction in older chronic patients based on drug prescription records
por: Kocbek, Simon, et al.
Publicado: (2018)

Improving Cardiac Resynchronisation Therapy
por: Thomas, George, et al.
Publicado: (2019)

Update in Cardiac Pacing
por: Verma, Nishant, et al.
Publicado: (2019)

Psychological flexibility and attitudes toward evidence-based interventions by amyotrophic lateral sclerosis patients
por: Pearlman, James R., et al.
Publicado: (2019)

Opioid distribution trends (2006–2017) in the US Territories
por: Cabrera, Fedor F., et al.
Publicado: (2019)

A combination of curcumin, vorinostat and silibinin reverses Aβ-induced nerve cell toxicity via activation of AKT-MDM2-p53 pathway
por: Meng, Jia, et al.
Publicado: (2019)

Construction, internal validation and implementation in a mobile application of a scoring system to predict nonadherence to proton pump inhibitors
por: Mares-García, Emma, et al.
Publicado: (2017)

The contribution of Nintendo Wii Fit series in the field of health: a systematic review and meta-analysis
por: Tripette, Julien, et al.
Publicado: (2017)

Technology-assisted white cane: evaluation and future directions
por: Khan, Izaz, et al.
Publicado: (2018)

Rapid screening mutations of first-line-drug-resistant genes in Mycobacterium tuberculosis strains by allele-specific real-time quantitative PCR
por: Yang, Pengpeng, et al.
Publicado: (2019)

Pacemaker and Defibrillator Implantation and Programming in Patients with Deep Brain Stimulation
por: Elliott, Mark, et al.
Publicado: (2019)

Implantable Cardiac Electronic Devices in the Elderly Population
por: Lim, Wei-Yao, et al.
Publicado: (2019)

Prostate cancer patients can benefit from 5-alpha-reductase inhibitor treatment: a meta-analysis
por: Deng, Tuo, et al.
Publicado: (2020)

Consolidation chemotherapy may improve pathological complete response for locally advanced rectal cancer after neoadjuvant chemoradiotherapy: a retrospective study
por: Cui, Jin, et al.
Publicado: (2020)

Unmasking Adenosine: The Purinergic Signalling Molecule Critical to Arrhythmia Pathophysiology and Management
por: Matthews, Gareth DK, et al.
Publicado: (2019)

Antimicrobial stewardship in remote primary healthcare across northern Australia
por: Cuningham, Will, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_v7p7bbc5n0k2sktd9a1cgghm9q