PhosY-secretome profiling combined with kinase-substrate interaction screening defines active c-Src-driven extracellular signaling

c-Src tyrosine kinase is a renowned key intracellular signaling molecule and a potential target for cancer therapy. Secreted c-Src is a recent observation, but how it contributes to extracellular phosphorylation remains elusive. Using a series of domain deletion mutants, we show that the N-proximal...

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Detalles Bibliográficos
Autores principales: Backe, Sarah J., Votra, SarahBeth D., Stokes, Matthew P., Sebestyén, Endre, Castelli, Matteo, Torielli, Luca, Colombo, Giorgio, Woodford, Mark R., Mollapour, Mehdi, Bourboulia, Dimitra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569185/
https://www.ncbi.nlm.nih.gov/pubmed/37243593
http://dx.doi.org/10.1016/j.celrep.2023.112539

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569185/
https://www.ncbi.nlm.nih.gov/pubmed/37243593
http://dx.doi.org/10.1016/j.celrep.2023.112539

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