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Hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-Michael addition
Partially hydrolysed poly(2-oxazoline)s possess unique properties. However, much of the focus in this area has been on water soluble poly(2-oxazoline)s. Where hydrophobic poly(2-oxazoline)s have been used, this is often for selective hydrolysis. However, hydrolysis of very hydrophobic polymers could...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569348/ https://www.ncbi.nlm.nih.gov/pubmed/37840642 http://dx.doi.org/10.1080/15685551.2023.2267232 |
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author | Drain, Ben A. Becer, Remzi C. |
author_facet | Drain, Ben A. Becer, Remzi C. |
author_sort | Drain, Ben A. |
collection | PubMed |
description | Partially hydrolysed poly(2-oxazoline)s possess unique properties. However, much of the focus in this area has been on water soluble poly(2-oxazoline)s. Where hydrophobic poly(2-oxazoline)s have been used, this is often for selective hydrolysis. However, hydrolysis of very hydrophobic polymers could lead to interesting solution behaviour. Herein, we describe universal conditions for the hydrolysis of poly(2-alkyl-2-oxazoline)s suitable for both hydrophobic and hydrophilic 2-oxazolines. We show that the system utilised gives comparable rates to that of water alone for poly(2-ethyl-2-oxazoline). In addition, poly(2-fatty acid-2-oxazoline) was hydrolysed using the developed system and was found to proceed in a controlled manner allowing the targeting of specific degrees of hydrolysis, albeit much slower than for poly(2-ethyl-2-oxazoline). Finally, we demonstrate the partial functionalisation of poly(2-oxazoline)-poly(ethylene imine) co-polymers via aza-Michael addition. |
format | Online Article Text |
id | pubmed-10569348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-105693482023-10-13 Hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-Michael addition Drain, Ben A. Becer, Remzi C. Des Monomers Polym Full Length Article Partially hydrolysed poly(2-oxazoline)s possess unique properties. However, much of the focus in this area has been on water soluble poly(2-oxazoline)s. Where hydrophobic poly(2-oxazoline)s have been used, this is often for selective hydrolysis. However, hydrolysis of very hydrophobic polymers could lead to interesting solution behaviour. Herein, we describe universal conditions for the hydrolysis of poly(2-alkyl-2-oxazoline)s suitable for both hydrophobic and hydrophilic 2-oxazolines. We show that the system utilised gives comparable rates to that of water alone for poly(2-ethyl-2-oxazoline). In addition, poly(2-fatty acid-2-oxazoline) was hydrolysed using the developed system and was found to proceed in a controlled manner allowing the targeting of specific degrees of hydrolysis, albeit much slower than for poly(2-ethyl-2-oxazoline). Finally, we demonstrate the partial functionalisation of poly(2-oxazoline)-poly(ethylene imine) co-polymers via aza-Michael addition. Taylor & Francis 2023-10-11 /pmc/articles/PMC10569348/ /pubmed/37840642 http://dx.doi.org/10.1080/15685551.2023.2267232 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent. |
spellingShingle | Full Length Article Drain, Ben A. Becer, Remzi C. Hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-Michael addition |
title | Hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-Michael addition |
title_full | Hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-Michael addition |
title_fullStr | Hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-Michael addition |
title_full_unstemmed | Hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-Michael addition |
title_short | Hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-Michael addition |
title_sort | hydrolysis of hydrophobic poly(2-oxazoline)s and their subsequent modification via aza-michael addition |
topic | Full Length Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569348/ https://www.ncbi.nlm.nih.gov/pubmed/37840642 http://dx.doi.org/10.1080/15685551.2023.2267232 |
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