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Roles of bacterial extracellular vesicles in systemic diseases

Accumulating evidence suggests that in various systems, not all bidirectional microbiota–host interactions involve direct cell contact. Bacterial extracellular vesicles (BEVs) may be key participants in this interkingdom crosstalk. BEVs mediate microbiota functions by delivering effector molecules t...

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Detalles Bibliográficos
Autores principales: Wang, Yanzhen, Luo, Xinghong, Xiang, Xiaozhen, Hao, Chunbo, Ma, Dandan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569430/
https://www.ncbi.nlm.nih.gov/pubmed/37840728
http://dx.doi.org/10.3389/fmicb.2023.1258860
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author Wang, Yanzhen
Luo, Xinghong
Xiang, Xiaozhen
Hao, Chunbo
Ma, Dandan
author_facet Wang, Yanzhen
Luo, Xinghong
Xiang, Xiaozhen
Hao, Chunbo
Ma, Dandan
author_sort Wang, Yanzhen
collection PubMed
description Accumulating evidence suggests that in various systems, not all bidirectional microbiota–host interactions involve direct cell contact. Bacterial extracellular vesicles (BEVs) may be key participants in this interkingdom crosstalk. BEVs mediate microbiota functions by delivering effector molecules that modulate host signaling pathways, thereby facilitating host–microbe interactions. BEV production during infections by both pathogens and probiotics has been observed in various host tissues. Therefore, these vesicles released by microbiota may have the ability to drive or inhibit disease pathogenesis in different systems within the host. Here, we review the current knowledge of BEVs and particularly emphasize their interactions with the host and the pathogenesis of systemic diseases.
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spelling pubmed-105694302023-10-13 Roles of bacterial extracellular vesicles in systemic diseases Wang, Yanzhen Luo, Xinghong Xiang, Xiaozhen Hao, Chunbo Ma, Dandan Front Microbiol Microbiology Accumulating evidence suggests that in various systems, not all bidirectional microbiota–host interactions involve direct cell contact. Bacterial extracellular vesicles (BEVs) may be key participants in this interkingdom crosstalk. BEVs mediate microbiota functions by delivering effector molecules that modulate host signaling pathways, thereby facilitating host–microbe interactions. BEV production during infections by both pathogens and probiotics has been observed in various host tissues. Therefore, these vesicles released by microbiota may have the ability to drive or inhibit disease pathogenesis in different systems within the host. Here, we review the current knowledge of BEVs and particularly emphasize their interactions with the host and the pathogenesis of systemic diseases. Frontiers Media S.A. 2023-09-28 /pmc/articles/PMC10569430/ /pubmed/37840728 http://dx.doi.org/10.3389/fmicb.2023.1258860 Text en Copyright © 2023 Wang, Luo, Xiang, Hao and Ma. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Wang, Yanzhen
Luo, Xinghong
Xiang, Xiaozhen
Hao, Chunbo
Ma, Dandan
Roles of bacterial extracellular vesicles in systemic diseases
title Roles of bacterial extracellular vesicles in systemic diseases
title_full Roles of bacterial extracellular vesicles in systemic diseases
title_fullStr Roles of bacterial extracellular vesicles in systemic diseases
title_full_unstemmed Roles of bacterial extracellular vesicles in systemic diseases
title_short Roles of bacterial extracellular vesicles in systemic diseases
title_sort roles of bacterial extracellular vesicles in systemic diseases
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569430/
https://www.ncbi.nlm.nih.gov/pubmed/37840728
http://dx.doi.org/10.3389/fmicb.2023.1258860
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