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Modeling functional cell types in spike train data

A major goal of computational neuroscience is to build accurate models of the activity of neurons that can be used to interpret their function in circuits. Here, we explore using functional cell types to refine single-cell models by grouping them into functionally relevant classes. Formally, we defi...

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Detalles Bibliográficos
Autores principales: Zdeblick, Daniel N., Shea-Brown, Eric T., Witten, Daniela M., Buice, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569560/
https://www.ncbi.nlm.nih.gov/pubmed/37824442
http://dx.doi.org/10.1371/journal.pcbi.1011509
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author Zdeblick, Daniel N.
Shea-Brown, Eric T.
Witten, Daniela M.
Buice, Michael A.
author_facet Zdeblick, Daniel N.
Shea-Brown, Eric T.
Witten, Daniela M.
Buice, Michael A.
author_sort Zdeblick, Daniel N.
collection PubMed
description A major goal of computational neuroscience is to build accurate models of the activity of neurons that can be used to interpret their function in circuits. Here, we explore using functional cell types to refine single-cell models by grouping them into functionally relevant classes. Formally, we define a hierarchical generative model for cell types, single-cell parameters, and neural responses, and then derive an expectation-maximization algorithm with variational inference that maximizes the likelihood of the neural recordings. We apply this “simultaneous” method to estimate cell types and fit single-cell models from simulated data, and find that it accurately recovers the ground truth parameters. We then apply our approach to in vitro neural recordings from neurons in mouse primary visual cortex, and find that it yields improved prediction of single-cell activity. We demonstrate that the discovered cell-type clusters are well separated and generalizable, and thus amenable to interpretation. We then compare discovered cluster memberships with locational, morphological, and transcriptomic data. Our findings reveal the potential to improve models of neural responses by explicitly allowing for shared functional properties across neurons.
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spelling pubmed-105695602023-10-13 Modeling functional cell types in spike train data Zdeblick, Daniel N. Shea-Brown, Eric T. Witten, Daniela M. Buice, Michael A. PLoS Comput Biol Research Article A major goal of computational neuroscience is to build accurate models of the activity of neurons that can be used to interpret their function in circuits. Here, we explore using functional cell types to refine single-cell models by grouping them into functionally relevant classes. Formally, we define a hierarchical generative model for cell types, single-cell parameters, and neural responses, and then derive an expectation-maximization algorithm with variational inference that maximizes the likelihood of the neural recordings. We apply this “simultaneous” method to estimate cell types and fit single-cell models from simulated data, and find that it accurately recovers the ground truth parameters. We then apply our approach to in vitro neural recordings from neurons in mouse primary visual cortex, and find that it yields improved prediction of single-cell activity. We demonstrate that the discovered cell-type clusters are well separated and generalizable, and thus amenable to interpretation. We then compare discovered cluster memberships with locational, morphological, and transcriptomic data. Our findings reveal the potential to improve models of neural responses by explicitly allowing for shared functional properties across neurons. Public Library of Science 2023-10-12 /pmc/articles/PMC10569560/ /pubmed/37824442 http://dx.doi.org/10.1371/journal.pcbi.1011509 Text en © 2023 Zdeblick et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zdeblick, Daniel N.
Shea-Brown, Eric T.
Witten, Daniela M.
Buice, Michael A.
Modeling functional cell types in spike train data
title Modeling functional cell types in spike train data
title_full Modeling functional cell types in spike train data
title_fullStr Modeling functional cell types in spike train data
title_full_unstemmed Modeling functional cell types in spike train data
title_short Modeling functional cell types in spike train data
title_sort modeling functional cell types in spike train data
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569560/
https://www.ncbi.nlm.nih.gov/pubmed/37824442
http://dx.doi.org/10.1371/journal.pcbi.1011509
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