Haemophagocytic lymphohistiocytosis after intravesical BCG administration for bladder cancer presenting with multiorgan failure

Bacillus Calmette-Guérin (BCG), is administered intravesically as an adjuvant immunotherapy for the treatment of non-muscle invasive bladder cancer. While mild non-infectious problems can occur in up to 85 % of cases, significant local and systemic complications have been reported in 1–5 % of cases....

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Autores principales: Liatsos, G. D., Manousopoulou, G., Poulaki, A., Iliaki, A., Mariolis, I., Vassilopoulos, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569663/
https://www.ncbi.nlm.nih.gov/pubmed/37841100
http://dx.doi.org/10.1099/acmi.0.000670.v3
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author Liatsos, G. D.
Manousopoulou, G.
Poulaki, A.
Iliaki, A.
Mariolis, I.
Vassilopoulos, D.
author_facet Liatsos, G. D.
Manousopoulou, G.
Poulaki, A.
Iliaki, A.
Mariolis, I.
Vassilopoulos, D.
author_sort Liatsos, G. D.
collection PubMed
description Bacillus Calmette-Guérin (BCG), is administered intravesically as an adjuvant immunotherapy for the treatment of non-muscle invasive bladder cancer. While mild non-infectious problems can occur in up to 85 % of cases, significant local and systemic complications have been reported in 1–5 % of cases. We report the case of a patient with superficial bladder cancer who developed multiorgan failure after intravesical BCG instillation including the kidney and liver with subsequent haemophagocytic lymphohistiocytosis. Our case illustrates the first reported combination of secondary haemophagocytic lymphohistiocytosis with severe renal and liver failure after BCG immunotherapy for bladder carcinoma. Treatment strategy is discussed.
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spelling pubmed-105696632023-10-13 Haemophagocytic lymphohistiocytosis after intravesical BCG administration for bladder cancer presenting with multiorgan failure Liatsos, G. D. Manousopoulou, G. Poulaki, A. Iliaki, A. Mariolis, I. Vassilopoulos, D. Access Microbiol Case Reports Bacillus Calmette-Guérin (BCG), is administered intravesically as an adjuvant immunotherapy for the treatment of non-muscle invasive bladder cancer. While mild non-infectious problems can occur in up to 85 % of cases, significant local and systemic complications have been reported in 1–5 % of cases. We report the case of a patient with superficial bladder cancer who developed multiorgan failure after intravesical BCG instillation including the kidney and liver with subsequent haemophagocytic lymphohistiocytosis. Our case illustrates the first reported combination of secondary haemophagocytic lymphohistiocytosis with severe renal and liver failure after BCG immunotherapy for bladder carcinoma. Treatment strategy is discussed. Microbiology Society 2023-09-29 /pmc/articles/PMC10569663/ /pubmed/37841100 http://dx.doi.org/10.1099/acmi.0.000670.v3 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License.
spellingShingle Case Reports
Liatsos, G. D.
Manousopoulou, G.
Poulaki, A.
Iliaki, A.
Mariolis, I.
Vassilopoulos, D.
Haemophagocytic lymphohistiocytosis after intravesical BCG administration for bladder cancer presenting with multiorgan failure
title Haemophagocytic lymphohistiocytosis after intravesical BCG administration for bladder cancer presenting with multiorgan failure
title_full Haemophagocytic lymphohistiocytosis after intravesical BCG administration for bladder cancer presenting with multiorgan failure
title_fullStr Haemophagocytic lymphohistiocytosis after intravesical BCG administration for bladder cancer presenting with multiorgan failure
title_full_unstemmed Haemophagocytic lymphohistiocytosis after intravesical BCG administration for bladder cancer presenting with multiorgan failure
title_short Haemophagocytic lymphohistiocytosis after intravesical BCG administration for bladder cancer presenting with multiorgan failure
title_sort haemophagocytic lymphohistiocytosis after intravesical bcg administration for bladder cancer presenting with multiorgan failure
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569663/
https://www.ncbi.nlm.nih.gov/pubmed/37841100
http://dx.doi.org/10.1099/acmi.0.000670.v3
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