Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs

The natural phenolic compound ellagic acid exerts anti-cancer effects, including activity against colorectal cancer (CRC). Previously, we reported that ellagic acid can inhibit the proliferation of CRC, and can induce cell cycle arrest and apoptosis. This study investigated ellagic acid-mediated ant...

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Autores principales: Zhao, Jinlu, Li, Guodong, Ren, Yi, Zhang, Zhicheng, Chen, Hongsheng, Zhang, Haopeng, Zhao, Xingyu, Li, Wang, Jia, Yucheng, Guan, Xue, Liu, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Pre-Clinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569677/
https://www.ncbi.nlm.nih.gov/pubmed/36847079
http://dx.doi.org/10.1097/CAD.0000000000001513
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author Zhao, Jinlu
Li, Guodong
Ren, Yi
Zhang, Zhicheng
Chen, Hongsheng
Zhang, Haopeng
Zhao, Xingyu
Li, Wang
Jia, Yucheng
Guan, Xue
Liu, Ming
author_facet Zhao, Jinlu
Li, Guodong
Ren, Yi
Zhang, Zhicheng
Chen, Hongsheng
Zhang, Haopeng
Zhao, Xingyu
Li, Wang
Jia, Yucheng
Guan, Xue
Liu, Ming
author_sort Zhao, Jinlu
collection PubMed
description The natural phenolic compound ellagic acid exerts anti-cancer effects, including activity against colorectal cancer (CRC). Previously, we reported that ellagic acid can inhibit the proliferation of CRC, and can induce cell cycle arrest and apoptosis. This study investigated ellagic acid-mediated anticancer effects using the human colon cancer HCT-116 cell line. After 72 h of ellagic acid treatment, a total of 206 long noncoding RNAs (lncRNAs) with differential expression greater than 1.5-fold were identified (115 down-regulated and 91 up-regulated). Furthermore, the co-expression network analysis of differentially expressed lncRNA and mRNA showed that differential expressed lncRNA might be the target of ellagic acid activity in inhibiting CRC.
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spelling pubmed-105696772023-10-13 Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs Zhao, Jinlu Li, Guodong Ren, Yi Zhang, Zhicheng Chen, Hongsheng Zhang, Haopeng Zhao, Xingyu Li, Wang Jia, Yucheng Guan, Xue Liu, Ming Anticancer Drugs Pre-Clinical Reports The natural phenolic compound ellagic acid exerts anti-cancer effects, including activity against colorectal cancer (CRC). Previously, we reported that ellagic acid can inhibit the proliferation of CRC, and can induce cell cycle arrest and apoptosis. This study investigated ellagic acid-mediated anticancer effects using the human colon cancer HCT-116 cell line. After 72 h of ellagic acid treatment, a total of 206 long noncoding RNAs (lncRNAs) with differential expression greater than 1.5-fold were identified (115 down-regulated and 91 up-regulated). Furthermore, the co-expression network analysis of differentially expressed lncRNA and mRNA showed that differential expressed lncRNA might be the target of ellagic acid activity in inhibiting CRC. Lippincott Williams & Wilkins 2023-11 2023-03-24 /pmc/articles/PMC10569677/ /pubmed/36847079 http://dx.doi.org/10.1097/CAD.0000000000001513 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Pre-Clinical Reports
Zhao, Jinlu
Li, Guodong
Ren, Yi
Zhang, Zhicheng
Chen, Hongsheng
Zhang, Haopeng
Zhao, Xingyu
Li, Wang
Jia, Yucheng
Guan, Xue
Liu, Ming
Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs
title Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs
title_full Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs
title_fullStr Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs
title_full_unstemmed Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs
title_short Ellagic acid inhibits human colon cancer HCT-116 cells by regulating long noncoding RNAs
title_sort ellagic acid inhibits human colon cancer hct-116 cells by regulating long noncoding rnas
topic Pre-Clinical Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569677/
https://www.ncbi.nlm.nih.gov/pubmed/36847079
http://dx.doi.org/10.1097/CAD.0000000000001513
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