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The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research
The interplay between antibiotic resistance and bacterial fitness/virulence has attracted the interest of researchers for decades because of its therapeutic implications, since it is classically assumed that resistance usually entails certain biological costs. Reviews on this topic revise the publis...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569695/ https://www.ncbi.nlm.nih.gov/pubmed/37840717 http://dx.doi.org/10.3389/fmicb.2023.1270999 |
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author | Jordana-Lluch, Elena Barceló, Isabel Mª Escobar-Salom, María Estévez, Miguel A. Zamorano, Laura Gómez-Zorrilla, Silvia Sendra, Elena Oliver, Antonio Juan, Carlos |
author_facet | Jordana-Lluch, Elena Barceló, Isabel Mª Escobar-Salom, María Estévez, Miguel A. Zamorano, Laura Gómez-Zorrilla, Silvia Sendra, Elena Oliver, Antonio Juan, Carlos |
author_sort | Jordana-Lluch, Elena |
collection | PubMed |
description | The interplay between antibiotic resistance and bacterial fitness/virulence has attracted the interest of researchers for decades because of its therapeutic implications, since it is classically assumed that resistance usually entails certain biological costs. Reviews on this topic revise the published data from a general point of view, including studies based on clinical strains or in vitro-evolved mutants in which the resistance phenotype is seen as a final outcome, i.e., a combination of mechanisms. However, a review analyzing the resistance/fitness balance from the basic research perspective, compiling studies in which the different resistance pathways and respective biological costs are individually approached, was missing. Here we cover this gap, specifically focusing on Pseudomonas aeruginosa, a pathogen that stands out because of its extraordinary capacity for resistance development and for which a considerable number of recent and particular data on the interplay with fitness/virulence have been released. The revised information, split into horizontally-acquired vs. mutation-driven resistance, suggests a great complexity and even controversy in the resistance-fitness/virulence balance in the acute infection context, with results ranging from high costs linked to certain pathways to others that are seemingly cost-free or even cases of resistance mechanisms contributing to increased pathogenic capacities. The elusive mechanistic basis for some enigmatic data, knowledge gaps, and possibilities for therapeutic exploitation are discussed. The information gathered suggests that resistance-fitness/virulence interplay may be a source of potential antipseudomonal targets and thus, this review poses the elementary first step for the future development of these strategies harnessing certain resistance-associated biological burdens. |
format | Online Article Text |
id | pubmed-10569695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105696952023-10-13 The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research Jordana-Lluch, Elena Barceló, Isabel Mª Escobar-Salom, María Estévez, Miguel A. Zamorano, Laura Gómez-Zorrilla, Silvia Sendra, Elena Oliver, Antonio Juan, Carlos Front Microbiol Microbiology The interplay between antibiotic resistance and bacterial fitness/virulence has attracted the interest of researchers for decades because of its therapeutic implications, since it is classically assumed that resistance usually entails certain biological costs. Reviews on this topic revise the published data from a general point of view, including studies based on clinical strains or in vitro-evolved mutants in which the resistance phenotype is seen as a final outcome, i.e., a combination of mechanisms. However, a review analyzing the resistance/fitness balance from the basic research perspective, compiling studies in which the different resistance pathways and respective biological costs are individually approached, was missing. Here we cover this gap, specifically focusing on Pseudomonas aeruginosa, a pathogen that stands out because of its extraordinary capacity for resistance development and for which a considerable number of recent and particular data on the interplay with fitness/virulence have been released. The revised information, split into horizontally-acquired vs. mutation-driven resistance, suggests a great complexity and even controversy in the resistance-fitness/virulence balance in the acute infection context, with results ranging from high costs linked to certain pathways to others that are seemingly cost-free or even cases of resistance mechanisms contributing to increased pathogenic capacities. The elusive mechanistic basis for some enigmatic data, knowledge gaps, and possibilities for therapeutic exploitation are discussed. The information gathered suggests that resistance-fitness/virulence interplay may be a source of potential antipseudomonal targets and thus, this review poses the elementary first step for the future development of these strategies harnessing certain resistance-associated biological burdens. Frontiers Media S.A. 2023-09-28 /pmc/articles/PMC10569695/ /pubmed/37840717 http://dx.doi.org/10.3389/fmicb.2023.1270999 Text en Copyright © 2023 Jordana-Lluch, Barceló, Escobar-Salom, Estévez, Zamorano, Gómez-Zorrilla, Sendra, Oliver and Juan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Jordana-Lluch, Elena Barceló, Isabel Mª Escobar-Salom, María Estévez, Miguel A. Zamorano, Laura Gómez-Zorrilla, Silvia Sendra, Elena Oliver, Antonio Juan, Carlos The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research |
title | The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research |
title_full | The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research |
title_fullStr | The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research |
title_full_unstemmed | The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research |
title_short | The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research |
title_sort | balance between antibiotic resistance and fitness/virulence in pseudomonas aeruginosa: an update on basic knowledge and fundamental research |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569695/ https://www.ncbi.nlm.nih.gov/pubmed/37840717 http://dx.doi.org/10.3389/fmicb.2023.1270999 |
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