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Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies
Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people (IDP) has focused on cancer and organ transplantation populations. In a prospective cohort of 195 IDP and 35 healthy volunteers (HV), antispike immunoglobulin G (IgG) was detected in 88% of IDP after dose 2, incre...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569702/ https://www.ncbi.nlm.nih.gov/pubmed/37824621 http://dx.doi.org/10.1126/sciadv.adh3150 |
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author | Zendt, Mackenzie Bustos Carrillo, Fausto A. Kelly, Sophie Saturday, Taylor DeGrange, Maureen Ginigeme, Anita Wu, Lurline Callier, Viviane Ortega-Villa, Ana Faust, Mondreakest Chang-Rabley, Emma Bugal, Kara Kenney, Heather Khil, Pavel Youn, Jung-Ho Osei, Gloria Regmi, Pravesh Anderson, Victoria Bosticardo, Marita Daub, Janine DiMaggio, Thomas Kreuzburg, Samantha Pala, Francesca Pfister, Justina Treat, Jennifer Ulrick, Jean Karkanitsa, Maria Kalish, Heather Kuhns, Douglas B. Priel, Debra L. Fink, Danielle L. Tsang, John S. Sparks, Rachel Uzel, Gulbu Waldman, Meryl A. Zerbe, Christa S. Delmonte, Ottavia M. Bergerson, Jenna R. E. Das, Sanchita Freeman, Alexandra F. Lionakis, Michail S. Sadtler, Kaitlyn van Doremalen, Neeltje Munster, Vincent Notarangelo, Luigi D. Holland, Steven M. Ricotta, Emily E. |
author_facet | Zendt, Mackenzie Bustos Carrillo, Fausto A. Kelly, Sophie Saturday, Taylor DeGrange, Maureen Ginigeme, Anita Wu, Lurline Callier, Viviane Ortega-Villa, Ana Faust, Mondreakest Chang-Rabley, Emma Bugal, Kara Kenney, Heather Khil, Pavel Youn, Jung-Ho Osei, Gloria Regmi, Pravesh Anderson, Victoria Bosticardo, Marita Daub, Janine DiMaggio, Thomas Kreuzburg, Samantha Pala, Francesca Pfister, Justina Treat, Jennifer Ulrick, Jean Karkanitsa, Maria Kalish, Heather Kuhns, Douglas B. Priel, Debra L. Fink, Danielle L. Tsang, John S. Sparks, Rachel Uzel, Gulbu Waldman, Meryl A. Zerbe, Christa S. Delmonte, Ottavia M. Bergerson, Jenna R. E. Das, Sanchita Freeman, Alexandra F. Lionakis, Michail S. Sadtler, Kaitlyn van Doremalen, Neeltje Munster, Vincent Notarangelo, Luigi D. Holland, Steven M. Ricotta, Emily E. |
author_sort | Zendt, Mackenzie |
collection | PubMed |
description | Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people (IDP) has focused on cancer and organ transplantation populations. In a prospective cohort of 195 IDP and 35 healthy volunteers (HV), antispike immunoglobulin G (IgG) was detected in 88% of IDP after dose 2, increasing to 93% by 6 months after dose 3. Despite high seroconversion, median IgG levels for IDP never surpassed one-third that of HV. IgG binding to Omicron BA.1 was lowest among variants. Angiotensin-converting enzyme 2 pseudo-neutralization only modestly correlated with antispike IgG concentration. IgG levels were not significantly altered by receipt of different messenger RNA–based vaccines, immunomodulating treatments, and prior severe acute respiratory syndrome coronavirus 2 infections. While our data show that three doses of coronavirus disease 2019 vaccinations induce antispike IgG in most IDP, additional doses are needed to increase protection. Because of the notably reduced IgG response to Omicron BA.1, the efficacy of additional vaccinations, including bivalent vaccines, should be studied in this population. |
format | Online Article Text |
id | pubmed-10569702 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-105697022023-10-13 Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies Zendt, Mackenzie Bustos Carrillo, Fausto A. Kelly, Sophie Saturday, Taylor DeGrange, Maureen Ginigeme, Anita Wu, Lurline Callier, Viviane Ortega-Villa, Ana Faust, Mondreakest Chang-Rabley, Emma Bugal, Kara Kenney, Heather Khil, Pavel Youn, Jung-Ho Osei, Gloria Regmi, Pravesh Anderson, Victoria Bosticardo, Marita Daub, Janine DiMaggio, Thomas Kreuzburg, Samantha Pala, Francesca Pfister, Justina Treat, Jennifer Ulrick, Jean Karkanitsa, Maria Kalish, Heather Kuhns, Douglas B. Priel, Debra L. Fink, Danielle L. Tsang, John S. Sparks, Rachel Uzel, Gulbu Waldman, Meryl A. Zerbe, Christa S. Delmonte, Ottavia M. Bergerson, Jenna R. E. Das, Sanchita Freeman, Alexandra F. Lionakis, Michail S. Sadtler, Kaitlyn van Doremalen, Neeltje Munster, Vincent Notarangelo, Luigi D. Holland, Steven M. Ricotta, Emily E. Sci Adv Biomedicine and Life Sciences Research on coronavirus disease 2019 vaccination in immune-deficient/disordered people (IDP) has focused on cancer and organ transplantation populations. In a prospective cohort of 195 IDP and 35 healthy volunteers (HV), antispike immunoglobulin G (IgG) was detected in 88% of IDP after dose 2, increasing to 93% by 6 months after dose 3. Despite high seroconversion, median IgG levels for IDP never surpassed one-third that of HV. IgG binding to Omicron BA.1 was lowest among variants. Angiotensin-converting enzyme 2 pseudo-neutralization only modestly correlated with antispike IgG concentration. IgG levels were not significantly altered by receipt of different messenger RNA–based vaccines, immunomodulating treatments, and prior severe acute respiratory syndrome coronavirus 2 infections. While our data show that three doses of coronavirus disease 2019 vaccinations induce antispike IgG in most IDP, additional doses are needed to increase protection. Because of the notably reduced IgG response to Omicron BA.1, the efficacy of additional vaccinations, including bivalent vaccines, should be studied in this population. American Association for the Advancement of Science 2023-10-12 /pmc/articles/PMC10569702/ /pubmed/37824621 http://dx.doi.org/10.1126/sciadv.adh3150 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY). https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Biomedicine and Life Sciences Zendt, Mackenzie Bustos Carrillo, Fausto A. Kelly, Sophie Saturday, Taylor DeGrange, Maureen Ginigeme, Anita Wu, Lurline Callier, Viviane Ortega-Villa, Ana Faust, Mondreakest Chang-Rabley, Emma Bugal, Kara Kenney, Heather Khil, Pavel Youn, Jung-Ho Osei, Gloria Regmi, Pravesh Anderson, Victoria Bosticardo, Marita Daub, Janine DiMaggio, Thomas Kreuzburg, Samantha Pala, Francesca Pfister, Justina Treat, Jennifer Ulrick, Jean Karkanitsa, Maria Kalish, Heather Kuhns, Douglas B. Priel, Debra L. Fink, Danielle L. Tsang, John S. Sparks, Rachel Uzel, Gulbu Waldman, Meryl A. Zerbe, Christa S. Delmonte, Ottavia M. Bergerson, Jenna R. E. Das, Sanchita Freeman, Alexandra F. Lionakis, Michail S. Sadtler, Kaitlyn van Doremalen, Neeltje Munster, Vincent Notarangelo, Luigi D. Holland, Steven M. Ricotta, Emily E. Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies |
title | Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies |
title_full | Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies |
title_fullStr | Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies |
title_full_unstemmed | Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies |
title_short | Characterization of the antispike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies |
title_sort | characterization of the antispike igg immune response to covid-19 vaccines in people with a wide variety of immunodeficiencies |
topic | Biomedicine and Life Sciences |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569702/ https://www.ncbi.nlm.nih.gov/pubmed/37824621 http://dx.doi.org/10.1126/sciadv.adh3150 |
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