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Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex

Neural population activity determines the timing of synaptic inputs, which arrive to dendrites, cell bodies, and axon initial segments (AISs) of cortical neurons. Action potential initiation in the AIS (AIS-APs) is driven by input integration, and the phase preference of AIS-APs during network oscil...

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Autores principales: Rózsa, Márton, Tóth, Martin, Oláh, Gáspár, Baka, Judith, Lákovics, Rajmund, Barzó, Pál, Tamás, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569705/
https://www.ncbi.nlm.nih.gov/pubmed/37824608
http://dx.doi.org/10.1126/sciadv.ade4511
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author Rózsa, Márton
Tóth, Martin
Oláh, Gáspár
Baka, Judith
Lákovics, Rajmund
Barzó, Pál
Tamás, Gábor
author_facet Rózsa, Márton
Tóth, Martin
Oláh, Gáspár
Baka, Judith
Lákovics, Rajmund
Barzó, Pál
Tamás, Gábor
author_sort Rózsa, Márton
collection PubMed
description Neural population activity determines the timing of synaptic inputs, which arrive to dendrites, cell bodies, and axon initial segments (AISs) of cortical neurons. Action potential initiation in the AIS (AIS-APs) is driven by input integration, and the phase preference of AIS-APs during network oscillations is characteristic to cell classes. Distal regions of cortical axons do not receive synaptic inputs, yet experimental induction protocols can trigger retroaxonal action potentials (RA-APs) in axons distal from the soma. We report spontaneously occurring RA-APs in human and rodent cortical interneurons that appear uncorrelated to inputs and population activity. Network-linked triggering of AIS-APs versus input-independent timing of RA-APs of the same interneurons results in disparate temporal contribution of a single cell to in vivo network operation through perisomatic and distal axonal firing.
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spelling pubmed-105697052023-10-13 Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex Rózsa, Márton Tóth, Martin Oláh, Gáspár Baka, Judith Lákovics, Rajmund Barzó, Pál Tamás, Gábor Sci Adv Neuroscience Neural population activity determines the timing of synaptic inputs, which arrive to dendrites, cell bodies, and axon initial segments (AISs) of cortical neurons. Action potential initiation in the AIS (AIS-APs) is driven by input integration, and the phase preference of AIS-APs during network oscillations is characteristic to cell classes. Distal regions of cortical axons do not receive synaptic inputs, yet experimental induction protocols can trigger retroaxonal action potentials (RA-APs) in axons distal from the soma. We report spontaneously occurring RA-APs in human and rodent cortical interneurons that appear uncorrelated to inputs and population activity. Network-linked triggering of AIS-APs versus input-independent timing of RA-APs of the same interneurons results in disparate temporal contribution of a single cell to in vivo network operation through perisomatic and distal axonal firing. American Association for the Advancement of Science 2023-10-12 /pmc/articles/PMC10569705/ /pubmed/37824608 http://dx.doi.org/10.1126/sciadv.ade4511 Text en Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Neuroscience
Rózsa, Márton
Tóth, Martin
Oláh, Gáspár
Baka, Judith
Lákovics, Rajmund
Barzó, Pál
Tamás, Gábor
Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
title Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
title_full Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
title_fullStr Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
title_full_unstemmed Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
title_short Temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
title_sort temporal disparity of action potentials triggered in axon initial segments and distal axons in the neocortex
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569705/
https://www.ncbi.nlm.nih.gov/pubmed/37824608
http://dx.doi.org/10.1126/sciadv.ade4511
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