CSF3R T618I Collaborates With RUNX1-RUNX1T1 to Expand Hematopoietic Progenitors and Sensitizes to GLI Inhibition

Activating colony-stimulating factor-3 receptor gene (CSF3R) mutations are recurrent in acute myeloid leukemia (AML) with t(8;21) translocation. However, the nature of oncogenic collaboration between alterations of CSF3R and the t(8;21) associated RUNX1-RUNX1T1 fusion remains unclear. In CD34+ hemat...

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Detalles Bibliográficos
Autores principales: Swoboda, Anja S., Arfelli, Vanessa C., Danese, Anna, Windisch, Roland, Kerbs, Paul, Redondo Monte, Enric, Bagnoli, Johannes W., Chen-Wichmann, Linping, Caroleo, Alessandra, Cusan, Monica, Krebs, Stefan, Blum, Helmut, Sterr, Michael, Enard, Wolfgang, Herold, Tobias, Colomé-Tatché, Maria, Wichmann, Christian, Greif, Philipp A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569757/
https://www.ncbi.nlm.nih.gov/pubmed/37841755
http://dx.doi.org/10.1097/HS9.0000000000000958

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