Erythrocyte invasion-neutralising antibodies prevent Plasmodium falciparum RH5 from binding to basigin-containing membrane protein complexes

Basigin is an essential host receptor for invasion of Plasmodium falciparum into human erythrocytes, interacting with parasite surface protein PfRH5. PfRH5 is a leading blood-stage malaria vaccine candidate and a target of growth-inhibitory antibodies. Here, we show that erythrocyte basigin is exclu...

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Detalles Bibliográficos
Autores principales: Jamwal, Abhishek, Constantin, Cristina F, Hirschi, Stephan, Henrich, Sebastian, Bildl, Wolfgang, Fakler, Bernd, Draper, Simon J, Schulte, Uwe, Higgins, Matthew K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Microbiology and Infectious Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569788/
https://www.ncbi.nlm.nih.gov/pubmed/37796723
http://dx.doi.org/10.7554/eLife.83681

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