Estimating the true stability of the prehydrolytic outward-facing state in an ABC protein

CFTR, the anion channel mutated in cystic fibrosis patients, is a model ABC protein whose ATP-driven conformational cycle is observable at single-molecule level in patch-clamp recordings. Bursts of CFTR pore openings are coupled to tight dimerization of its two nucleotide-binding domains (NBDs) and...

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Detalles Bibliográficos
Autores principales: Simon, Márton A, Iordanov, Iordan, Szollosi, Andras, Csanády, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569789/
https://www.ncbi.nlm.nih.gov/pubmed/37782012
http://dx.doi.org/10.7554/eLife.90736

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569789/
https://www.ncbi.nlm.nih.gov/pubmed/37782012
http://dx.doi.org/10.7554/eLife.90736

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