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Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review

Rheumatoid arthritis (RA), a chronic inflammatory disease primarily affecting synovial joints and tendons, can potentially impact various organs within the body. One notable complication associated with RA is upper cervical spine instability, medically termed atlantoaxial subluxation (AAS). This con...

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Autores principales: Subagio, Eko Agus, Wicaksono, Pandu, Faris, Muhammad, Bajamal, Abdul Hafid, Abdillah, Diaz Syafrie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569890/
https://www.ncbi.nlm.nih.gov/pubmed/37841539
http://dx.doi.org/10.1155/2023/6675489
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author Subagio, Eko Agus
Wicaksono, Pandu
Faris, Muhammad
Bajamal, Abdul Hafid
Abdillah, Diaz Syafrie
author_facet Subagio, Eko Agus
Wicaksono, Pandu
Faris, Muhammad
Bajamal, Abdul Hafid
Abdillah, Diaz Syafrie
author_sort Subagio, Eko Agus
collection PubMed
description Rheumatoid arthritis (RA), a chronic inflammatory disease primarily affecting synovial joints and tendons, can potentially impact various organs within the body. One notable complication associated with RA is upper cervical spine instability, medically termed atlantoaxial subluxation (AAS). This condition can lead to adverse consequences, including chronic myelopathy and acute mechanical compression of the medulla oblongata, with the potential for sudden death. While AAS may often remain asymptomatic, some nonspecific symptoms, such as neck pain, have been documented. Severe atlantoaxial subluxation can trigger more distinct symptoms, including delayed occipital pain attributed to the compression of the exiting C2 nerve root. Recent studies have elucidated a spectrum of symptoms preceding sudden death, encompassing vertigo, dizziness, convulsions, dysphagia, disorientation, and seizures. Remarkably, some cases have reported sudden death occurring during sleep. Historical data reveal a fluctuating incidence of this phenomenon, with eleven cases reported between 1969 and 1975 and six cases documented between 1990 and 2010. Notably, one of the most prevalent causes of sudden mortality in individuals with RA is the acute mechanical damage inflicted upon the medulla oblongata due to atlantoaxial subluxation.
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spelling pubmed-105698902023-10-13 Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review Subagio, Eko Agus Wicaksono, Pandu Faris, Muhammad Bajamal, Abdul Hafid Abdillah, Diaz Syafrie ScientificWorldJournal Review Article Rheumatoid arthritis (RA), a chronic inflammatory disease primarily affecting synovial joints and tendons, can potentially impact various organs within the body. One notable complication associated with RA is upper cervical spine instability, medically termed atlantoaxial subluxation (AAS). This condition can lead to adverse consequences, including chronic myelopathy and acute mechanical compression of the medulla oblongata, with the potential for sudden death. While AAS may often remain asymptomatic, some nonspecific symptoms, such as neck pain, have been documented. Severe atlantoaxial subluxation can trigger more distinct symptoms, including delayed occipital pain attributed to the compression of the exiting C2 nerve root. Recent studies have elucidated a spectrum of symptoms preceding sudden death, encompassing vertigo, dizziness, convulsions, dysphagia, disorientation, and seizures. Remarkably, some cases have reported sudden death occurring during sleep. Historical data reveal a fluctuating incidence of this phenomenon, with eleven cases reported between 1969 and 1975 and six cases documented between 1990 and 2010. Notably, one of the most prevalent causes of sudden mortality in individuals with RA is the acute mechanical damage inflicted upon the medulla oblongata due to atlantoaxial subluxation. Hindawi 2023-10-05 /pmc/articles/PMC10569890/ /pubmed/37841539 http://dx.doi.org/10.1155/2023/6675489 Text en Copyright © 2023 Eko Agus Subagio et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Subagio, Eko Agus
Wicaksono, Pandu
Faris, Muhammad
Bajamal, Abdul Hafid
Abdillah, Diaz Syafrie
Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review
title Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review
title_full Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review
title_fullStr Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review
title_full_unstemmed Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review
title_short Diagnosis and Prevalence (1975–2010) of Sudden Death due to Atlantoaxial Subluxation in Cervical Rheumatoid Arthritis: A Literature Review
title_sort diagnosis and prevalence (1975–2010) of sudden death due to atlantoaxial subluxation in cervical rheumatoid arthritis: a literature review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569890/
https://www.ncbi.nlm.nih.gov/pubmed/37841539
http://dx.doi.org/10.1155/2023/6675489
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