Optimisation of TP53 reporters by systematic dissection of synthetic TP53 response elements

TP53 is a transcription factor that controls multiple cellular processes, including cell cycle arrest, DNA repair and apoptosis. The relation between TP53 binding site architecture and transcriptional output is still not fully understood. Here, we systematically examined in three different cell line...

Descripción completa

Detalles Bibliográficos
Autores principales: Trauernicht, Max, Rastogi, Chaitanya, Manzo, Stefano G, Bussemaker, Harmen J, van Steensel, Bas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570033/
https://www.ncbi.nlm.nih.gov/pubmed/37650627
http://dx.doi.org/10.1093/nar/gkad718

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570033/
https://www.ncbi.nlm.nih.gov/pubmed/37650627
http://dx.doi.org/10.1093/nar/gkad718

Ejemplares similares