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Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits

eIF2A was the first eukaryotic initiator tRNA carrier discovered but its exact function has remained enigmatic. Uncharacteristic of translation initiation factors, eIF2A is reported to be non-cytosolic in multiple human cancer cell lines. Attempts to study eIF2A mechanistically have been limited by...

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Detalles Bibliográficos
Autores principales:	Grove, Daisy J, Levine, Daniel J, Kearse, Michael G
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570035/ https://www.ncbi.nlm.nih.gov/pubmed/37602404 http://dx.doi.org/10.1093/nar/gkad683

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