CRISPR screens in sister chromatid cohesion defective cells reveal PAXIP1-PAGR1 as regulator of chromatin association of cohesin

The cohesin complex regulates higher order chromosome architecture through maintaining sister chromatid cohesion and folding chromatin by DNA loop extrusion. Impaired cohesin function underlies a heterogeneous group of genetic syndromes and is associated with cancer. Here, we mapped the genetic depe...

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Detalles Bibliográficos
Autores principales: van Schie, Janne J M, de Lint, Klaas, Molenaar, Thom M, Moronta Gines, Macarena, Balk, Jesper A, Rooimans, Martin A, Roohollahi, Khashayar, Pai, Govind M, Borghuis, Lauri, Ramadhin, Anisha R, Corazza, Francesco, Dorsman, Josephine C, Wendt, Kerstin S, Wolthuis, Rob M F, de Lange, Job
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570055/
https://www.ncbi.nlm.nih.gov/pubmed/37702151
http://dx.doi.org/10.1093/nar/gkad756

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