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Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort

Identifying cardiovascular-related measures that track from early childhood into later ages may help inform early prevention targets for cardiovascular disease. In this study, the tracking of triglycerides (TG), high-density cholesterol (HDL-c), atherogenic coefficient (AC), waist circumference to h...

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Autores principales: Fernández-Iglesias, Rocío, Martinez-Camblor, Pablo, Fernández-Somoano, Ana, Rodríguez-Dehli, Cristina, Venta-Obaya, Rafael, Karagas, Margaret R., Tardón, Adonina, Riaño-Galán, Isolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570156/
https://www.ncbi.nlm.nih.gov/pubmed/37338691
http://dx.doi.org/10.1007/s00431-023-05051-8
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author Fernández-Iglesias, Rocío
Martinez-Camblor, Pablo
Fernández-Somoano, Ana
Rodríguez-Dehli, Cristina
Venta-Obaya, Rafael
Karagas, Margaret R.
Tardón, Adonina
Riaño-Galán, Isolina
author_facet Fernández-Iglesias, Rocío
Martinez-Camblor, Pablo
Fernández-Somoano, Ana
Rodríguez-Dehli, Cristina
Venta-Obaya, Rafael
Karagas, Margaret R.
Tardón, Adonina
Riaño-Galán, Isolina
author_sort Fernández-Iglesias, Rocío
collection PubMed
description Identifying cardiovascular-related measures that track from early childhood into later ages may help inform early prevention targets for cardiovascular disease. In this study, the tracking of triglycerides (TG), high-density cholesterol (HDL-c), atherogenic coefficient (AC), waist circumference to height ratio (WC/Height), mean arterial pressure (MAP), and homeostatic model assessment of insulin resistance (HOMA-IR) was examined in the INMA-Asturias cohort between 4 and 8 years of age. The analysis was conducted in 307 children who participated in the INMA-Asturias cohort (Spain) at 4 and at 8 years of age. Quantile regression models were used to evaluate tracking between measures at both ages, with each measure at 8 years as the dependent variable and the rank transformation of the same measure at 4 years as the independent variable. We found a positive association between HDL-c rank at 4 years and higher quantiles of the HDL-c distribution at 8 years, with an increase of 2.93 mg/dL (95% CI: 1.98, 3.87) per decile in the 0.9 quantile. A positive association was also found for WC/Height, with an increase of 0.008 (95% CI: 0.004, 0.012) per decile in the 0.9 quantile. We observed that tracking for AC increased in the higher quantiles of the distribution at 8 years, with an increase of 0.11 (95% CI: 0.09, 0.14) in the 0.6 quantile compared to an effect of 0.15 (95% CI: 0.09, 0.21) in the 0.9 quantile.   Conclusions: Adult markers of dyslipidemia and central obesity tracked between ages 4 and 8 years. For AC, tracking increased in the higher quantiles of the distribution. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00431-023-05051-8.
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spelling pubmed-105701562023-10-14 Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort Fernández-Iglesias, Rocío Martinez-Camblor, Pablo Fernández-Somoano, Ana Rodríguez-Dehli, Cristina Venta-Obaya, Rafael Karagas, Margaret R. Tardón, Adonina Riaño-Galán, Isolina Eur J Pediatr Research Identifying cardiovascular-related measures that track from early childhood into later ages may help inform early prevention targets for cardiovascular disease. In this study, the tracking of triglycerides (TG), high-density cholesterol (HDL-c), atherogenic coefficient (AC), waist circumference to height ratio (WC/Height), mean arterial pressure (MAP), and homeostatic model assessment of insulin resistance (HOMA-IR) was examined in the INMA-Asturias cohort between 4 and 8 years of age. The analysis was conducted in 307 children who participated in the INMA-Asturias cohort (Spain) at 4 and at 8 years of age. Quantile regression models were used to evaluate tracking between measures at both ages, with each measure at 8 years as the dependent variable and the rank transformation of the same measure at 4 years as the independent variable. We found a positive association between HDL-c rank at 4 years and higher quantiles of the HDL-c distribution at 8 years, with an increase of 2.93 mg/dL (95% CI: 1.98, 3.87) per decile in the 0.9 quantile. A positive association was also found for WC/Height, with an increase of 0.008 (95% CI: 0.004, 0.012) per decile in the 0.9 quantile. We observed that tracking for AC increased in the higher quantiles of the distribution at 8 years, with an increase of 0.11 (95% CI: 0.09, 0.14) in the 0.6 quantile compared to an effect of 0.15 (95% CI: 0.09, 0.21) in the 0.9 quantile.   Conclusions: Adult markers of dyslipidemia and central obesity tracked between ages 4 and 8 years. For AC, tracking increased in the higher quantiles of the distribution. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00431-023-05051-8. Springer Berlin Heidelberg 2023-06-20 2023 /pmc/articles/PMC10570156/ /pubmed/37338691 http://dx.doi.org/10.1007/s00431-023-05051-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Fernández-Iglesias, Rocío
Martinez-Camblor, Pablo
Fernández-Somoano, Ana
Rodríguez-Dehli, Cristina
Venta-Obaya, Rafael
Karagas, Margaret R.
Tardón, Adonina
Riaño-Galán, Isolina
Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
title Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
title_full Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
title_fullStr Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
title_full_unstemmed Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
title_short Tracking between cardiovascular-related measures at 4 and 8 years of age in the INMA-Asturias cohort
title_sort tracking between cardiovascular-related measures at 4 and 8 years of age in the inma-asturias cohort
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570156/
https://www.ncbi.nlm.nih.gov/pubmed/37338691
http://dx.doi.org/10.1007/s00431-023-05051-8
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