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MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort

BACKGROUND: The rs641738 C > T single-nucleotide polymorphism of MBOAT7 has been associated with hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Latin Americans have high rates of HCC and NAFLD, but no assessment between MBOAT7 and HCC has been performed in this popul...

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Autores principales: Goble, Spencer, Akambase, Joseph, Prieto, Jhon, Balderramo, Domingo, Ferrer, Javier Diaz, Mattos, Angelo Z., Arrese, Marco, Carrera, Enrique, Groothuismink, Zwier M. A., Oliveira, Jeffrey, Boonstra, Andre, Debes, Jose D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570183/
https://www.ncbi.nlm.nih.gov/pubmed/37684433
http://dx.doi.org/10.1007/s10620-023-08104-y
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author Goble, Spencer
Akambase, Joseph
Prieto, Jhon
Balderramo, Domingo
Ferrer, Javier Diaz
Mattos, Angelo Z.
Arrese, Marco
Carrera, Enrique
Groothuismink, Zwier M. A.
Oliveira, Jeffrey
Boonstra, Andre
Debes, Jose D.
author_facet Goble, Spencer
Akambase, Joseph
Prieto, Jhon
Balderramo, Domingo
Ferrer, Javier Diaz
Mattos, Angelo Z.
Arrese, Marco
Carrera, Enrique
Groothuismink, Zwier M. A.
Oliveira, Jeffrey
Boonstra, Andre
Debes, Jose D.
author_sort Goble, Spencer
collection PubMed
description BACKGROUND: The rs641738 C > T single-nucleotide polymorphism of MBOAT7 has been associated with hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Latin Americans have high rates of HCC and NAFLD, but no assessment between MBOAT7 and HCC has been performed in this population. AIMS: We provide the first assessment of the impact of MBOAT7 on HCC risk in Latin Americans. METHODS: Patients were prospectively recruited into the ESCALON network, designed to collect samples from Latin American patients with HCC in 6 South American countries (Argentina, Ecuador, Brazil, Chile, Peru, and Colombia). A European cohort and the general Hispanic population of gnomAD database were included for comparison. Associations between HCC and MBOAT7 were evaluated using logistic regression. RESULTS: In total, 310 cases of HCC and 493 cases of cirrhosis without HCC were assessed. The MBOAT7 TT genotype was not predictive of HCC in Latin Americans (TT vs CC OR adjusted = 1.15, 95% CI 0.66–2.01, p = 0.610) or Europeans (TT vs CC OR adjusted = 1.20, 95% CI 0.59–2.43, p = 0.621). No significant association was noted on subgroup analysis for NAFLD, viral hepatitis, or alcohol-related liver disease. The TT genotype was increased in the NAFLD-cirrhosis cohort of Latin Americans compared to a non-cirrhotic NAFLD cohort (TT vs CC + CT OR = 2.75, 95% CI 1.10–6.87, p = 0.031). CONCLUSION: The rs631738 C > T allele of MBOAT7 was not associated with increased risk of HCC in Latin Americans or Europeans. An increase in the risk of cirrhosis was noted with the TT genotype in Latin Americans with NAFLD. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-105701832023-10-14 MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort Goble, Spencer Akambase, Joseph Prieto, Jhon Balderramo, Domingo Ferrer, Javier Diaz Mattos, Angelo Z. Arrese, Marco Carrera, Enrique Groothuismink, Zwier M. A. Oliveira, Jeffrey Boonstra, Andre Debes, Jose D. Dig Dis Sci Original Article BACKGROUND: The rs641738 C > T single-nucleotide polymorphism of MBOAT7 has been associated with hepatocellular carcinoma (HCC) and nonalcoholic fatty liver disease (NAFLD). Latin Americans have high rates of HCC and NAFLD, but no assessment between MBOAT7 and HCC has been performed in this population. AIMS: We provide the first assessment of the impact of MBOAT7 on HCC risk in Latin Americans. METHODS: Patients were prospectively recruited into the ESCALON network, designed to collect samples from Latin American patients with HCC in 6 South American countries (Argentina, Ecuador, Brazil, Chile, Peru, and Colombia). A European cohort and the general Hispanic population of gnomAD database were included for comparison. Associations between HCC and MBOAT7 were evaluated using logistic regression. RESULTS: In total, 310 cases of HCC and 493 cases of cirrhosis without HCC were assessed. The MBOAT7 TT genotype was not predictive of HCC in Latin Americans (TT vs CC OR adjusted = 1.15, 95% CI 0.66–2.01, p = 0.610) or Europeans (TT vs CC OR adjusted = 1.20, 95% CI 0.59–2.43, p = 0.621). No significant association was noted on subgroup analysis for NAFLD, viral hepatitis, or alcohol-related liver disease. The TT genotype was increased in the NAFLD-cirrhosis cohort of Latin Americans compared to a non-cirrhotic NAFLD cohort (TT vs CC + CT OR = 2.75, 95% CI 1.10–6.87, p = 0.031). CONCLUSION: The rs631738 C > T allele of MBOAT7 was not associated with increased risk of HCC in Latin Americans or Europeans. An increase in the risk of cirrhosis was noted with the TT genotype in Latin Americans with NAFLD. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2023-09-08 2023 /pmc/articles/PMC10570183/ /pubmed/37684433 http://dx.doi.org/10.1007/s10620-023-08104-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Article
Goble, Spencer
Akambase, Joseph
Prieto, Jhon
Balderramo, Domingo
Ferrer, Javier Diaz
Mattos, Angelo Z.
Arrese, Marco
Carrera, Enrique
Groothuismink, Zwier M. A.
Oliveira, Jeffrey
Boonstra, Andre
Debes, Jose D.
MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort
title MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort
title_full MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort
title_fullStr MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort
title_full_unstemmed MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort
title_short MBOAT7 rs641738 Variant Is Not Associated with an Increased Risk of Hepatocellular Carcinoma in a Latin American Cohort
title_sort mboat7 rs641738 variant is not associated with an increased risk of hepatocellular carcinoma in a latin american cohort
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570183/
https://www.ncbi.nlm.nih.gov/pubmed/37684433
http://dx.doi.org/10.1007/s10620-023-08104-y
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