The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances

In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated. The res...

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Autores principales: Li, Lili, Zhao, Jianghui, Ma, Fengcang, He, Daihua, Liu, Ping, Li, Wei, Zhang, Ke, Chen, Xiaohong, Song, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Biomaterials Synthesis and Characterization
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570214/
https://www.ncbi.nlm.nih.gov/pubmed/37823900
http://dx.doi.org/10.1007/s10856-023-06755-x
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author Li, Lili
Zhao, Jianghui
Ma, Fengcang
He, Daihua
Liu, Ping
Li, Wei
Zhang, Ke
Chen, Xiaohong
Song, Lin
author_facet Li, Lili
Zhao, Jianghui
Ma, Fengcang
He, Daihua
Liu, Ping
Li, Wei
Zhang, Ke
Chen, Xiaohong
Song, Lin
author_sort Li, Lili
collection PubMed
description In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated. The results showed that ICA@Mg-ZIF-8 has the same morphology and crystal structure as ZIF-8. ICA@Mg-ZIF-8 showed enhanced antibacterial activity against Escherichia coli and Staphylococcus aureus, and the antibacterial rate was increased to 87.7 % and 64.0 %, respectively. The results of in vitro mineralization showed that ICA@Mg-ZIF-8 presented better osteogenic performance promoting the uniform deposition of more calcium and phosphorus in simulated body fluids compared to ZIF-8. GRAPHICAL ABSTRACT: [Image: see text]
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spelling pubmed-105702142023-10-14 The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances Li, Lili Zhao, Jianghui Ma, Fengcang He, Daihua Liu, Ping Li, Wei Zhang, Ke Chen, Xiaohong Song, Lin J Mater Sci Mater Med Biomaterials Synthesis and Characterization In this study, ICA@Mg-ZIF-8 was synthesized by Mg doping in ZIF-8 and loaded with icariin (ICA). The morphologies and phases were observed and analyzed by SEM, XRD, and the release behaviors of Mg, Zn ions and ICA were tested. Its antibacterial and mineralization performances were evaluated. The results showed that ICA@Mg-ZIF-8 has the same morphology and crystal structure as ZIF-8. ICA@Mg-ZIF-8 showed enhanced antibacterial activity against Escherichia coli and Staphylococcus aureus, and the antibacterial rate was increased to 87.7 % and 64.0 %, respectively. The results of in vitro mineralization showed that ICA@Mg-ZIF-8 presented better osteogenic performance promoting the uniform deposition of more calcium and phosphorus in simulated body fluids compared to ZIF-8. GRAPHICAL ABSTRACT: [Image: see text] Springer US 2023-10-12 2023 /pmc/articles/PMC10570214/ /pubmed/37823900 http://dx.doi.org/10.1007/s10856-023-06755-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Biomaterials Synthesis and Characterization
Li, Lili
Zhao, Jianghui
Ma, Fengcang
He, Daihua
Liu, Ping
Li, Wei
Zhang, Ke
Chen, Xiaohong
Song, Lin
The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances
title The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances
title_full The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances
title_fullStr The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances
title_full_unstemmed The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances
title_short The Mg doping ZIF-8 loaded with Icariin and its antibacterial and osteogenic performances
title_sort mg doping zif-8 loaded with icariin and its antibacterial and osteogenic performances
topic Biomaterials Synthesis and Characterization
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570214/
https://www.ncbi.nlm.nih.gov/pubmed/37823900
http://dx.doi.org/10.1007/s10856-023-06755-x
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