Cargando…
Clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery
We aimed to analyse the clinical characteristics of children with different types of anomalous aortic origin of the coronary artery (AAOCA) at different ages, and to discuss the factors related to myocardial ischaemia. In this retrospective study, we included 69 children diagnosed with AAOCA using C...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570235/ https://www.ncbi.nlm.nih.gov/pubmed/37436520 http://dx.doi.org/10.1007/s00431-023-05075-0 |
_version_ | 1785119718457212928 |
---|---|
author | Zhen, Zhen Dong, Ziyan Na, Jia Chen, Xi Li, Qirui Gao, Lu Yuan, Yue |
author_facet | Zhen, Zhen Dong, Ziyan Na, Jia Chen, Xi Li, Qirui Gao, Lu Yuan, Yue |
author_sort | Zhen, Zhen |
collection | PubMed |
description | We aimed to analyse the clinical characteristics of children with different types of anomalous aortic origin of the coronary artery (AAOCA) at different ages, and to discuss the factors related to myocardial ischaemia. In this retrospective study, we included 69 children diagnosed with AAOCA using CT coronary angiography; we classified the participants based on the type of AAOCA, age, and high-risk anatomy. The clinical characteristics of the different AAOCA types and age groups were compared, and the correlation between manifestations and high-risk anatomy was analysed. Anomalous origin of the left coronary artery from the right coronary artery sinus, anomalous origin of the right coronary artery from the left coronary artery sinus, and a coronary artery origin without coronary sinuses was found in 10 (14.5%), 57 (82.6%), 2 (2.9%) patients, respectively. There were no significant differences in sex, clinical manifestations, percentage of positive myocardial injury markers, electrocardiogram, transthoracic echocardiography, or proportion of high-risk anatomy among the groups with different AAOCA types. According to age group, the proportion of asymptomatic infants and pre-schoolers was the highest (p < 0.001). Forty-three patients (62.3%) had high-risk anatomy and were more likely to present with severe symptoms and cardiac syncope (p < 0.05). Conclusion: There were no significant differences in the proportions of high-risk anatomy and clinical characteristics among children with different AAOCA types. We found a relation between the severity of AAOCA clinical symptoms and anatomical risk. |
format | Online Article Text |
id | pubmed-10570235 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-105702352023-10-14 Clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery Zhen, Zhen Dong, Ziyan Na, Jia Chen, Xi Li, Qirui Gao, Lu Yuan, Yue Eur J Pediatr Research We aimed to analyse the clinical characteristics of children with different types of anomalous aortic origin of the coronary artery (AAOCA) at different ages, and to discuss the factors related to myocardial ischaemia. In this retrospective study, we included 69 children diagnosed with AAOCA using CT coronary angiography; we classified the participants based on the type of AAOCA, age, and high-risk anatomy. The clinical characteristics of the different AAOCA types and age groups were compared, and the correlation between manifestations and high-risk anatomy was analysed. Anomalous origin of the left coronary artery from the right coronary artery sinus, anomalous origin of the right coronary artery from the left coronary artery sinus, and a coronary artery origin without coronary sinuses was found in 10 (14.5%), 57 (82.6%), 2 (2.9%) patients, respectively. There were no significant differences in sex, clinical manifestations, percentage of positive myocardial injury markers, electrocardiogram, transthoracic echocardiography, or proportion of high-risk anatomy among the groups with different AAOCA types. According to age group, the proportion of asymptomatic infants and pre-schoolers was the highest (p < 0.001). Forty-three patients (62.3%) had high-risk anatomy and were more likely to present with severe symptoms and cardiac syncope (p < 0.05). Conclusion: There were no significant differences in the proportions of high-risk anatomy and clinical characteristics among children with different AAOCA types. We found a relation between the severity of AAOCA clinical symptoms and anatomical risk. Springer Berlin Heidelberg 2023-07-12 2023 /pmc/articles/PMC10570235/ /pubmed/37436520 http://dx.doi.org/10.1007/s00431-023-05075-0 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Research Zhen, Zhen Dong, Ziyan Na, Jia Chen, Xi Li, Qirui Gao, Lu Yuan, Yue Clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery |
title | Clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery |
title_full | Clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery |
title_fullStr | Clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery |
title_full_unstemmed | Clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery |
title_short | Clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery |
title_sort | clinical analysis of sixty-nine children with anomalous aortic origin of the coronary artery |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570235/ https://www.ncbi.nlm.nih.gov/pubmed/37436520 http://dx.doi.org/10.1007/s00431-023-05075-0 |
work_keys_str_mv | AT zhenzhen clinicalanalysisofsixtyninechildrenwithanomalousaorticoriginofthecoronaryartery AT dongziyan clinicalanalysisofsixtyninechildrenwithanomalousaorticoriginofthecoronaryartery AT najia clinicalanalysisofsixtyninechildrenwithanomalousaorticoriginofthecoronaryartery AT chenxi clinicalanalysisofsixtyninechildrenwithanomalousaorticoriginofthecoronaryartery AT liqirui clinicalanalysisofsixtyninechildrenwithanomalousaorticoriginofthecoronaryartery AT gaolu clinicalanalysisofsixtyninechildrenwithanomalousaorticoriginofthecoronaryartery AT yuanyue clinicalanalysisofsixtyninechildrenwithanomalousaorticoriginofthecoronaryartery |