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Impact of COVID infection on lung function test and quality of life
Post-COVID-19 pulmonary sequalae are well-recognized early in the pandemic. Survivorship clinics are crucial for managing at-risk patients. However, it is unclear who requires pulmonary function test (PFT) and when PFTs should be performed. We aim to investigate for whom and how these interval PFTs...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570308/ https://www.ncbi.nlm.nih.gov/pubmed/37828107 http://dx.doi.org/10.1038/s41598-023-43710-w |
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author | Toh, Ming Ren Teo, Ying Rachel Poh, Li Choo Ruby Tang, Yiting Soh, Rui Ya Sharma, Kiran Kalyanasundaram, Ganesh Poh, Kai Chin |
author_facet | Toh, Ming Ren Teo, Ying Rachel Poh, Li Choo Ruby Tang, Yiting Soh, Rui Ya Sharma, Kiran Kalyanasundaram, Ganesh Poh, Kai Chin |
author_sort | Toh, Ming Ren |
collection | PubMed |
description | Post-COVID-19 pulmonary sequalae are well-recognized early in the pandemic. Survivorship clinics are crucial for managing at-risk patients. However, it is unclear who requires pulmonary function test (PFT) and when PFTs should be performed. We aim to investigate for whom and how these interval PFTs should be performed. We performed a single-centre, prospective cohort study on COVID-19 survivors between 1st May 2020 and 31st April 2022. These patients were followed up at 6, 9 and 12 months with interval PFT and Short Form-36 (SF-36) Health Survey. Those with PFT defects were offered a computed tomography scan of the thorax. Of the 46 patients recruited, 17 (37%) had severe/critical illness. Compared to those with mild/moderate disease, these patients were more likely to experience DLCO defects (59% versus 17%, p = 0.005) and had lower SF-36 scores (mean physical component summary score of 45 ± 12 versus 52 ± 8, p = 0.046). These differences were most notable at 6 months, compared to the 9- and 12-months intervals. DLCO defects were also associated with older age, raised inflammatory markers and extensive CXR infiltrates. Besides interstitial-like abnormalities, obesity and undiagnosed lung conditions accounted for 39% of the PFT abnormalities. Interval PFTs can be performed earliest 6 months post-COVID-19. Patients with normal tests were unlikely to develop new abnormalities and would not require repeat PFTs. Abnormal PFTs can be followed-up with repeat PFTs 6 monthly until resolution. Non-COVID-19 differentials should be considered for persistent PFT abnormalities. |
format | Online Article Text |
id | pubmed-10570308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-105703082023-10-14 Impact of COVID infection on lung function test and quality of life Toh, Ming Ren Teo, Ying Rachel Poh, Li Choo Ruby Tang, Yiting Soh, Rui Ya Sharma, Kiran Kalyanasundaram, Ganesh Poh, Kai Chin Sci Rep Article Post-COVID-19 pulmonary sequalae are well-recognized early in the pandemic. Survivorship clinics are crucial for managing at-risk patients. However, it is unclear who requires pulmonary function test (PFT) and when PFTs should be performed. We aim to investigate for whom and how these interval PFTs should be performed. We performed a single-centre, prospective cohort study on COVID-19 survivors between 1st May 2020 and 31st April 2022. These patients were followed up at 6, 9 and 12 months with interval PFT and Short Form-36 (SF-36) Health Survey. Those with PFT defects were offered a computed tomography scan of the thorax. Of the 46 patients recruited, 17 (37%) had severe/critical illness. Compared to those with mild/moderate disease, these patients were more likely to experience DLCO defects (59% versus 17%, p = 0.005) and had lower SF-36 scores (mean physical component summary score of 45 ± 12 versus 52 ± 8, p = 0.046). These differences were most notable at 6 months, compared to the 9- and 12-months intervals. DLCO defects were also associated with older age, raised inflammatory markers and extensive CXR infiltrates. Besides interstitial-like abnormalities, obesity and undiagnosed lung conditions accounted for 39% of the PFT abnormalities. Interval PFTs can be performed earliest 6 months post-COVID-19. Patients with normal tests were unlikely to develop new abnormalities and would not require repeat PFTs. Abnormal PFTs can be followed-up with repeat PFTs 6 monthly until resolution. Non-COVID-19 differentials should be considered for persistent PFT abnormalities. Nature Publishing Group UK 2023-10-12 /pmc/articles/PMC10570308/ /pubmed/37828107 http://dx.doi.org/10.1038/s41598-023-43710-w Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Toh, Ming Ren Teo, Ying Rachel Poh, Li Choo Ruby Tang, Yiting Soh, Rui Ya Sharma, Kiran Kalyanasundaram, Ganesh Poh, Kai Chin Impact of COVID infection on lung function test and quality of life |
title | Impact of COVID infection on lung function test and quality of life |
title_full | Impact of COVID infection on lung function test and quality of life |
title_fullStr | Impact of COVID infection on lung function test and quality of life |
title_full_unstemmed | Impact of COVID infection on lung function test and quality of life |
title_short | Impact of COVID infection on lung function test and quality of life |
title_sort | impact of covid infection on lung function test and quality of life |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570308/ https://www.ncbi.nlm.nih.gov/pubmed/37828107 http://dx.doi.org/10.1038/s41598-023-43710-w |
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