Key advances in vaccine development for tuberculosis—success and challenges

Breakthrough findings in the clinical and preclinical development of tuberculosis (TB) vaccines have galvanized the field and suggest, for the first time since the development of bacille Calmette-Guérin (BCG), that a novel and protective TB vaccine is on the horizon. Here we highlight the TB vaccine...

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Autores principales: Lai, Rocky, Ogunsola, Abiola F., Rakib, Tasfia, Behar, Samuel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570318/
https://www.ncbi.nlm.nih.gov/pubmed/37828070
http://dx.doi.org/10.1038/s41541-023-00750-7
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author Lai, Rocky
Ogunsola, Abiola F.
Rakib, Tasfia
Behar, Samuel M.
author_facet Lai, Rocky
Ogunsola, Abiola F.
Rakib, Tasfia
Behar, Samuel M.
author_sort Lai, Rocky
collection PubMed
description Breakthrough findings in the clinical and preclinical development of tuberculosis (TB) vaccines have galvanized the field and suggest, for the first time since the development of bacille Calmette-Guérin (BCG), that a novel and protective TB vaccine is on the horizon. Here we highlight the TB vaccines that are in the development pipeline and review the basis for optimism in both the clinical and preclinical space. We describe immune signatures that could act as immunological correlates of protection (CoP) to facilitate the development and comparison of vaccines. Finally, we discuss new animal models that are expected to more faithfully model the pathology and complex immune responses observed in human populations.
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spelling pubmed-105703182023-10-14 Key advances in vaccine development for tuberculosis—success and challenges Lai, Rocky Ogunsola, Abiola F. Rakib, Tasfia Behar, Samuel M. NPJ Vaccines Review Article Breakthrough findings in the clinical and preclinical development of tuberculosis (TB) vaccines have galvanized the field and suggest, for the first time since the development of bacille Calmette-Guérin (BCG), that a novel and protective TB vaccine is on the horizon. Here we highlight the TB vaccines that are in the development pipeline and review the basis for optimism in both the clinical and preclinical space. We describe immune signatures that could act as immunological correlates of protection (CoP) to facilitate the development and comparison of vaccines. Finally, we discuss new animal models that are expected to more faithfully model the pathology and complex immune responses observed in human populations. Nature Publishing Group UK 2023-10-13 /pmc/articles/PMC10570318/ /pubmed/37828070 http://dx.doi.org/10.1038/s41541-023-00750-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Lai, Rocky
Ogunsola, Abiola F.
Rakib, Tasfia
Behar, Samuel M.
Key advances in vaccine development for tuberculosis—success and challenges
title Key advances in vaccine development for tuberculosis—success and challenges
title_full Key advances in vaccine development for tuberculosis—success and challenges
title_fullStr Key advances in vaccine development for tuberculosis—success and challenges
title_full_unstemmed Key advances in vaccine development for tuberculosis—success and challenges
title_short Key advances in vaccine development for tuberculosis—success and challenges
title_sort key advances in vaccine development for tuberculosis—success and challenges
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570318/
https://www.ncbi.nlm.nih.gov/pubmed/37828070
http://dx.doi.org/10.1038/s41541-023-00750-7
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