Oncogenic context shapes the fitness landscape of tumor suppression

Tumors acquire alterations in oncogenes and tumor suppressor genes in an adaptive walk through the fitness landscape of tumorigenesis. However, the interactions between oncogenes and tumor suppressor genes that shape this landscape remain poorly resolved and cannot be revealed by human cancer genomi...

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Detalles Bibliográficos
Autores principales: Blair, Lily M., Juan, Joseph M., Sebastian, Lafia, Tran, Vy B., Nie, Wensheng, Wall, Gregory D., Gerceker, Mehmet, Lai, Ian K., Apilado, Edwin A., Grenot, Gabriel, Amar, David, Foggetti, Giorgia, Do Carmo, Mariana, Ugur, Zeynep, Deng, Debbie, Chenchik, Alex, Paz Zafra, Maria, Dow, Lukas E., Politi, Katerina, MacQuitty, Jonathan J., Petrov, Dmitri A., Winslow, Monte M., Rosen, Michael J., Winters, Ian P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570323/
https://www.ncbi.nlm.nih.gov/pubmed/37828026
http://dx.doi.org/10.1038/s41467-023-42156-y

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