Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content

Megalin/LRP2 is a major receptor supporting apical endocytosis in kidney proximal tubular cells. We have previously reported that kidney-specific perinatal ablation of the megalin gene in cystinotic mice, a model of nephropathic cystinosis, essentially blocks renal cystine accumulation and partially...

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Detalles Bibliográficos
Autores principales: Rega, L. R., Janssens, V., Graversen, J. H., Moestrup, S. K., Cairoli, S., Goffredo, B. M., Nevo, N., Courtoy, G. E., Jouret, F., Antignac, C., Emma, F., Pierreux, C. E., Courtoy, P. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570359/
https://www.ncbi.nlm.nih.gov/pubmed/37828038
http://dx.doi.org/10.1038/s41598-023-43105-x

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