DARPins detect the formation of hetero-tetramers of p63 and p73 in epithelial tissues and in squamous cell carcinoma

The two p53 homologues p63 and p73 regulate transcriptional programs in epithelial tissues and several cell types in these tissues express both proteins. All members of the p53 family form tetramers in their active state through a dedicated oligomerization domain that structurally assembles as a dim...

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Detalles Bibliográficos
Autores principales: Strubel, Alexander, Münick, Philipp, Hartmann, Oliver, Chaikuad, Apirat, Dreier, Birgit, Schaefer, Jonas V., Gebel, Jakob, Osterburg, Christian, Tuppi, Marcel, Schäfer, Birgit, Buck, Viktoria, Rosenfeldt, Mathias, Knapp, Stefan, Plückthun, Andreas, Diefenbacher, Markus E., Dötsch, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570377/
https://www.ncbi.nlm.nih.gov/pubmed/37828008
http://dx.doi.org/10.1038/s41419-023-06213-0

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