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Pathophysiological concepts and screening of cardiovascular disease in dialysis patients
Dialysis patients experience 10–20 times higher cardiovascular mortality than the general population. The high burden of both conventional and nontraditional risk factors attributable to loss of renal function can explain higher rates of cardiovascular disease (CVD) morbidity and death among dialysi...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570458/ https://www.ncbi.nlm.nih.gov/pubmed/37840653 http://dx.doi.org/10.3389/fneph.2023.1198560 |
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author | Echefu, Gift Stowe, Ifeoluwa Burka, Semenawit Basu-Ray, Indranill Kumbala, Damodar |
author_facet | Echefu, Gift Stowe, Ifeoluwa Burka, Semenawit Basu-Ray, Indranill Kumbala, Damodar |
author_sort | Echefu, Gift |
collection | PubMed |
description | Dialysis patients experience 10–20 times higher cardiovascular mortality than the general population. The high burden of both conventional and nontraditional risk factors attributable to loss of renal function can explain higher rates of cardiovascular disease (CVD) morbidity and death among dialysis patients. As renal function declines, uremic toxins accumulate in the blood and disrupt cell function, causing cardiovascular damage. Hemodialysis patients have many cardiovascular complications, including sudden cardiac death. Peritoneal dialysis puts dialysis patients with end-stage renal disease at increased risk of CVD complications and emergency hospitalization. The current standard of care in this population is based on observational data, which has a high potential for bias due to the paucity of dedicated randomized clinical trials. Furthermore, guidelines lack specific guidelines for these patients, often inferring them from non-dialysis patient trials. A crucial step in the prevention and treatment of CVD would be to gain better knowledge of the influence of these predisposing risk factors. This review highlights the current evidence regarding the influence of advanced chronic disease on the cardiovascular system in patients undergoing renal dialysis. |
format | Online Article Text |
id | pubmed-10570458 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-105704582023-10-14 Pathophysiological concepts and screening of cardiovascular disease in dialysis patients Echefu, Gift Stowe, Ifeoluwa Burka, Semenawit Basu-Ray, Indranill Kumbala, Damodar Front Nephrol Nephrology Dialysis patients experience 10–20 times higher cardiovascular mortality than the general population. The high burden of both conventional and nontraditional risk factors attributable to loss of renal function can explain higher rates of cardiovascular disease (CVD) morbidity and death among dialysis patients. As renal function declines, uremic toxins accumulate in the blood and disrupt cell function, causing cardiovascular damage. Hemodialysis patients have many cardiovascular complications, including sudden cardiac death. Peritoneal dialysis puts dialysis patients with end-stage renal disease at increased risk of CVD complications and emergency hospitalization. The current standard of care in this population is based on observational data, which has a high potential for bias due to the paucity of dedicated randomized clinical trials. Furthermore, guidelines lack specific guidelines for these patients, often inferring them from non-dialysis patient trials. A crucial step in the prevention and treatment of CVD would be to gain better knowledge of the influence of these predisposing risk factors. This review highlights the current evidence regarding the influence of advanced chronic disease on the cardiovascular system in patients undergoing renal dialysis. Frontiers Media S.A. 2023-09-29 /pmc/articles/PMC10570458/ /pubmed/37840653 http://dx.doi.org/10.3389/fneph.2023.1198560 Text en Copyright © 2023 Echefu, Stowe, Burka, Basu-Ray and Kumbala https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nephrology Echefu, Gift Stowe, Ifeoluwa Burka, Semenawit Basu-Ray, Indranill Kumbala, Damodar Pathophysiological concepts and screening of cardiovascular disease in dialysis patients |
title | Pathophysiological concepts and screening of cardiovascular disease in dialysis patients |
title_full | Pathophysiological concepts and screening of cardiovascular disease in dialysis patients |
title_fullStr | Pathophysiological concepts and screening of cardiovascular disease in dialysis patients |
title_full_unstemmed | Pathophysiological concepts and screening of cardiovascular disease in dialysis patients |
title_short | Pathophysiological concepts and screening of cardiovascular disease in dialysis patients |
title_sort | pathophysiological concepts and screening of cardiovascular disease in dialysis patients |
topic | Nephrology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570458/ https://www.ncbi.nlm.nih.gov/pubmed/37840653 http://dx.doi.org/10.3389/fneph.2023.1198560 |
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