Cargando…

White matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways

BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) has been suggested to contribute to the pathogenesis of Alzheimer's disease (AD). Yet, the role of SVD in potentially contributing to AD pathology is unclear. The main objective of this study was to test the hypothesis that WMHs influe...

Descripción completa

Detalles Bibliográficos
Autores principales: Ali, Doaa G., Bahrani, Ahmed A., El Khouli, Riham H., Gold, Brian T., Jiang, Yang, Zachariou, Valentinos, Wilcock, Donna M., Jicha, Gregory A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570488/
https://www.ncbi.nlm.nih.gov/pubmed/37534614
http://dx.doi.org/10.1002/brb3.3209
_version_ 1785119779556687872
author Ali, Doaa G.
Bahrani, Ahmed A.
El Khouli, Riham H.
Gold, Brian T.
Jiang, Yang
Zachariou, Valentinos
Wilcock, Donna M.
Jicha, Gregory A.
author_facet Ali, Doaa G.
Bahrani, Ahmed A.
El Khouli, Riham H.
Gold, Brian T.
Jiang, Yang
Zachariou, Valentinos
Wilcock, Donna M.
Jicha, Gregory A.
author_sort Ali, Doaa G.
collection PubMed
description BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) has been suggested to contribute to the pathogenesis of Alzheimer's disease (AD). Yet, the role of SVD in potentially contributing to AD pathology is unclear. The main objective of this study was to test the hypothesis that WMHs influence amyloid β (Aβ) levels within connected default mode network (DMN) tracts and cortical regions in cognitively unimpaired older adults. METHODS: Regional standard uptake value ratios (SUVr) from Aβ‐PET and white matter hyperintensity (WMH) volumes from three‐dimensional magnetic resonance imaging FLAIR images were analyzed across a sample of 72 clinically unimpaired (mini‐mental state examination ≥26), older adults (mean age 74.96 and standard deviation 8.13) from the Alzheimer's Disease Neuroimaging Initiative (ADNI3). The association of WMH volumes in major fiber tracts projecting from cortical DMN regions and Aβ‐PET SUVr in the connected cortical DMN regions was analyzed using linear regression models adjusted for age, sex, ApoE, and total brain volumes. RESULTS: The regression analyses demonstrate that increased WMH volumes in the superior longitudinal fasciculus were associated with increased regional SUVr in the inferior parietal lobule (p = .011). CONCLUSION: The findings suggest that the relation between Aβ in parietal cortex is associated with SVD in downstream white matter (WM) pathways in preclinical AD. The biological relationships and interplay between Aβ and WM microstructure alterations that precede overt WMH development across the continuum of AD progression warrant further study.
format Online
Article
Text
id pubmed-10570488
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-105704882023-10-14 White matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways Ali, Doaa G. Bahrani, Ahmed A. El Khouli, Riham H. Gold, Brian T. Jiang, Yang Zachariou, Valentinos Wilcock, Donna M. Jicha, Gregory A. Brain Behav Original Articles BACKGROUND AND PURPOSE: Cerebral small vessel disease (SVD) has been suggested to contribute to the pathogenesis of Alzheimer's disease (AD). Yet, the role of SVD in potentially contributing to AD pathology is unclear. The main objective of this study was to test the hypothesis that WMHs influence amyloid β (Aβ) levels within connected default mode network (DMN) tracts and cortical regions in cognitively unimpaired older adults. METHODS: Regional standard uptake value ratios (SUVr) from Aβ‐PET and white matter hyperintensity (WMH) volumes from three‐dimensional magnetic resonance imaging FLAIR images were analyzed across a sample of 72 clinically unimpaired (mini‐mental state examination ≥26), older adults (mean age 74.96 and standard deviation 8.13) from the Alzheimer's Disease Neuroimaging Initiative (ADNI3). The association of WMH volumes in major fiber tracts projecting from cortical DMN regions and Aβ‐PET SUVr in the connected cortical DMN regions was analyzed using linear regression models adjusted for age, sex, ApoE, and total brain volumes. RESULTS: The regression analyses demonstrate that increased WMH volumes in the superior longitudinal fasciculus were associated with increased regional SUVr in the inferior parietal lobule (p = .011). CONCLUSION: The findings suggest that the relation between Aβ in parietal cortex is associated with SVD in downstream white matter (WM) pathways in preclinical AD. The biological relationships and interplay between Aβ and WM microstructure alterations that precede overt WMH development across the continuum of AD progression warrant further study. John Wiley and Sons Inc. 2023-08-03 /pmc/articles/PMC10570488/ /pubmed/37534614 http://dx.doi.org/10.1002/brb3.3209 Text en © 2023 The Authors. Brain and Behavior published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Ali, Doaa G.
Bahrani, Ahmed A.
El Khouli, Riham H.
Gold, Brian T.
Jiang, Yang
Zachariou, Valentinos
Wilcock, Donna M.
Jicha, Gregory A.
White matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways
title White matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways
title_full White matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways
title_fullStr White matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways
title_full_unstemmed White matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways
title_short White matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways
title_sort white matter hyperintensities influence distal cortical β‐amyloid accumulation in default mode network pathways
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10570488/
https://www.ncbi.nlm.nih.gov/pubmed/37534614
http://dx.doi.org/10.1002/brb3.3209
work_keys_str_mv AT alidoaag whitematterhyperintensitiesinfluencedistalcorticalbamyloidaccumulationindefaultmodenetworkpathways
AT bahraniahmeda whitematterhyperintensitiesinfluencedistalcorticalbamyloidaccumulationindefaultmodenetworkpathways
AT elkhoulirihamh whitematterhyperintensitiesinfluencedistalcorticalbamyloidaccumulationindefaultmodenetworkpathways
AT goldbriant whitematterhyperintensitiesinfluencedistalcorticalbamyloidaccumulationindefaultmodenetworkpathways
AT jiangyang whitematterhyperintensitiesinfluencedistalcorticalbamyloidaccumulationindefaultmodenetworkpathways
AT zachariouvalentinos whitematterhyperintensitiesinfluencedistalcorticalbamyloidaccumulationindefaultmodenetworkpathways
AT wilcockdonnam whitematterhyperintensitiesinfluencedistalcorticalbamyloidaccumulationindefaultmodenetworkpathways
AT jichagregorya whitematterhyperintensitiesinfluencedistalcorticalbamyloidaccumulationindefaultmodenetworkpathways